Cystic Fibrosis Mice Develop Spontaneous Chronic Bordetella Airway Infections.
Cystic Fibrosis Mice Develop Spontaneous Chronic Bordetella Airway Infections.
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DOI：
10.16966/2470-3176.128
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Drumm M
中科院分区：
文献类型：
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作者：
Darrah R;Bonfield T;LiPuma JJ;Litman P;Hodges CA;Jacono F;Drumm M
慢性肺部疾病和感染是囊性纤维化（CF）患者发病和死亡的主要原因。虽然铜绿假单胞菌最常见于CF患者的气道中，但人们越来越重视CF微生物组的多样性，包括其他分类群，如博德特氏菌。在这里，我们描述了在CF小鼠，以前没有被认为是自发性气道感染的假欣兹波氏杆菌感染的识别和影响。我们确定CF小鼠对B更敏感。pseudohinzii感染，并且比非CF小鼠更不能够解决感染。此外，在CF和非CF小鼠中，B. pseudohinzii感染导致呼吸频率显著降低和CF特异性免疫应答。这些结果确立了CF小鼠模型作为CF相关感染研究的重要工具，并突出了博德特氏菌对CF临床病理学的潜在贡献。
Chronic pulmonary disease and infection is the primary cause of morbidity and mortality in people with cystic fibrosis (CF). Though Pseudomonas aeruginosa, is most commonly found in the airways of individuals with CF, there is increasing appreciation for the diversity of the CF microbiome, including other taxa such as Bordetella. Here we describe the identification and impact of Bordetella pseudohinzii infection in CF mice, which previously have not been thought to develop spontaneous airway infections. We determined that CF mice are more susceptible to the B. pseudohinzii infections, and less able to resolve the infection than non-CF mice. Moreover, in both CF and non-CF mice, B. pseudohinzii infections lead to markedly reduced respiratory rates and a CF-specific immune response. These results establish the CF mouse model as an important tool for the study of CF-relevant infection and highlight the potential contribution of Bordetella to CF clinical pathology.