Occupation and Semen Parameters in a Cohort of Fertile Men.
Occupation and Semen Parameters in a Cohort of Fertile Men.
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DOI：
10.1097/jom.0000000000002607
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发表时间：
2022-10-01
影响因子：
3.2
通讯作者：
Swan, Shanna H.
中科院分区：
文献类型：
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作者：
Meyer, John D.;Brazil, Charlene;Redmon, J. Bruce;Wang, Christina;Sparks, Amy E.;Swan, Shanna H.
在未来家庭研究（SFF）中，我们研究了职业和精液参数之间的关系。采用广义线性模型评估职业和工作场所暴露与精液量、精子浓度、活力和形态的关系。在安装、维护和修理职业中，精子浓度和活力较低。在平均精子浓度较低的职业中，铅和其他有毒物质的暴露较高（铅的患病率为4.1;杀虫剂/杀虫剂为1.6;溶剂为1.4）。与铅接触超过3个月与精子浓度降低有关，工作以外的铅接触也是如此。我们发现证据表明，可生育的男性在铅、杀虫剂/除草剂和溶剂暴露下精子质量降低。这些结果可能会确定职业的男性生殖毒性保护措施可能是必要的。
We examined associations between occupation and semen parameters in demonstrably fertile men in the Study for Future Families (SFF). Associations of occupation and workplace exposures with semen volume, sperm concentration, motility, and morphology were assessed using generalized linear modeling. Lower sperm concentration and motility were seen in installation, maintenance, and repair occupations. Higher exposure to lead, and to other toxicants, was seen in occupations with lower mean sperm concentrations (for lead, prevalence ratio 4.1; pesticides/insecticides 1.6; solvents 1.4). Working with lead for >3 months was associated with lower sperm concentration, as was lead exposure outside of work. We found evidence in demonstrably fertile men for reduced sperm quality with lead, pesticide/herbicide and solvent exposure. These results may identify occupations where protective measures against male reproductive toxicity might be warranted.