A Review on Saliva-Based Health Diagnostics: Biomarker Selection and Future Directions.
A Review on Saliva-Based Health Diagnostics: Biomarker Selection and Future Directions.
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DOI：
10.1007/s44174-023-00090-z
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发表时间：
2023-06-06
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当人体出现问题时，它有一种独特的表达方式。体液中的分子可以通过促进健康和预防疾病进展来帮助早期发现疾病。这些能够改善医疗保健的生物标志物正在成为广泛的研究领域。检测这些生物标记物的生物传感器正在成为未来，尤其是无需亲自到医院的护理点 (POC) 生物传感器。使用生物传感器检测复杂的系统性疾病还有很长的路要走。基于唾液的生物传感器由于其非侵入性采集以及检测牙周病和识别全身性疾病的能力而在体液中受到关注。基于唾液的诊断生物传感器的可能性已经得到了广泛的宣传，各公司纷纷向家庭发送用于血统预测的套件。基于唾液的 covid 19 检测揭示了有效的临床用途和经济收集的相关性。基于通用生物标志物，系统性疾病的检测是一个蓬勃发展的研究领域。关于基于唾液的生物传感器有很多研究，但它作为 POC 设备仍然面临挑战和限制。这篇综述论文讨论了唾液的相关性及其作为生物传感器的有用性。此外，它还提供了需要考虑的建议，以使其成为可能的诊断工具。
The human body has a unique way of saying when something is wrong with it. The molecules in the body fluids can be helpful in the early detection of diseases by enabling health and preventing disease progression. These biomarkers enabling better healthcare are becoming an extensive area of research interest. Biosensors that detect these biomarkers are becoming the future, especially Point Of Care (POC) biosensors that remove the need to be physically present in the hospital. Detection of complex and systemic diseases using biosensors has a long way to go. Saliva-based biosensors are gaining attention among body fluids due to their non-invasive collection and ability to detect periodontal disease and identify systemic diseases. The possibility of saliva-based diagnostic biosensors has gained much publicity, with companies sending home kits for ancestry prediction. Saliva-based testing for covid 19 has revealed effective clinical use and relevance of the economic collection. Based on universal biomarkers, the detection of systemic diseases is a booming research arena. Lots of research on saliva-based biosensors is available, but it still poses challenges and limitations as POC devices. This review paper talks about the relevance of saliva and its usefulness as a biosensor. Also, it has recommendations that need to be considered to enable it as a possible diagnostic tool.