Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease
Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease
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DOI：
10.1093/oxfordjournals.aje.a008954
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发表时间：
1996-09-01
影响因子：
5
通讯作者：
Morens, DM
中科院分区：
文献类型：
--
作者：
Davis, JW;Grandinetti, A;Morens, DM
尿酸是一种在血清和大脑中发现的高浓度抗氧化剂，被假设可以防止帕金森病中的氧化损伤和细胞死亡。作者在参与一项名为“檀香山心脏计划”的为期 30 年的前瞻性研究的男性中测试了这一假设。在 1965 年至 1968 年举行的基线检查中，对 7,968 名男性进行了血清尿酸测量。在这些男性中，有 92 人随后患上了特发性帕金森病在针对年龄和吸烟情况进行调整的分析中，入组时尿酸浓度高于中位数的男性的 IPD 发病率降低了 40%（比率 (RR) = 0.6；95% 置信区间 (CI) 0.4-1.0），在仅限于非吸烟者（RR = 0.5；95% CI 0.3-1.0）和年龄小于 75 岁的病例的分析中，IPD 发病率持续降低（RR = 0.5；95% CI 0.3-0.9），当分析仅限于尿酸测量后 5 年以上发生的病例时，发病率并未受到显着影响（RR = 0.6；95% CI 0.4-1.0）。将已知或计算出的尿酸相关性纳入回归模型并没有显着改变 IPD 风险。这项研究提供了尿酸与 IPD 发生率降低之间关联的前瞻性证据，并表明有必要进一步研究这种关联。
Uric acid, an antioxidant found in high concentrations in serum and in the brain, has been hypothesized to protect against oxidative damage and cell death in Parkinson's disease, The authors tested this hypothesis among men participating in a 30-year prospective study known as the Honolulu Heart Program, Serum uric acid was measured in 7,968 men at the baseline examination held from 1965 to 1968, Of these men, 92 subsequently developed idiopathic Parkinson's disease (IPD), In analyses adjusted for age and smoking, men with uric acid concentrations above the median at enrollment had a 40% reduction in IPD incidence (rate ratio (RR) = 0.6; 95% confidence interval (CI) 0.4-1.0), Reduced IPD incidence rates persisted in analyses restricted to nonsmokers (RR = 0.5; 95% CI 0.3-1.0) and cases younger than age 75 years (RR = 0.5; 95% CI 0.3-0.9), Incidence rates were not notably affected when analyses were restricted to cases that occurred more than 5 years after uric acid measurement (RR = 0.6; 95% CI 0.4-1.0). Inclusion of known or computed correlates of uric acid in regression models did not substantially change risk of IPD, This study provides prospective evidence of an association between uric acid and reduced occurrence of IPD and indicates that further investigations of this association are warranted.