Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability
Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability
复制标题
具有锌释放能力的含锌氟化羟基磷灰石层的制备及评价
DOI：
10.1016/j.actbio.2007.08.013
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发表时间：
2008-03-01
影响因子：
9.7
通讯作者：
Zhang, Sam
中科院分区：
文献类型：
--
作者：
Miao, Shundong;Cheng, Kui;Zhang, Sam
采用溶胶-凝胶法制备了含锌β -磷酸三钙（ZnTCP）相和氟化羟基磷灰石（FHA）相在钛合金基体上的双相层。扫描电镜和能量色散x射线分析结果表明，ZnTCP/FHA层具有非均质表面，由ZnTCP颗粒团聚形成的微尺度凸形结构。该层具有缓慢而持续的锌释放行为。ZnTCP/FHA层的划痕测试结果为489 +/- 4 mN，表明该层与衬底界面结合良好。ZnTCP/FHA层支持细胞生长，与不含Zn的另一双相层（TCP/FHA）相比，细胞活力有统计学意义的提高。本研究表明，目前的双相ZnTCP/FHA层作为金属种植体生物活性涂层的最外层，在促进骨生长方面具有重要的作用。(C) 2007材料学报Elsevier Ltd.出版。版权所有。
A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surface with microscaled gibbous structures originating from ZnTCP particle agglomeration. This layer had a slow and sustained Zn release behavior. The scratch test result of the ZnTCP/FHA layer was 489 +/- 4 mN, indicating good interface bonding between the layer and substrate. The ZnTCP/FHA layer supported cell growth, and showed a statistically significant increase in cell viability in comparison with another biphasic layer (TCP/FHA) without Zn. This work demonstrates that the present biphasic ZnTCP/FHA layer has the potential to play a significant role in enhancing bone growth when used as the outermost part of bioactive coatings on metallic implants. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.