Liver enzymes and incident diabetes - Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Liver enzymes and incident diabetes - Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
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DOI：
10.2337/dc07-2159
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发表时间：
2008-06-01
期刊：
影响因子：
16.2
通讯作者：
Boeing, Heiner
中科院分区：
文献类型：
--
作者：
Ford, Earl S.;Schulze, Matthias B.;Boeing, Heiner
目的：前瞻性地研究肝酶-谷氨酰转移酶（GGT）和谷丙转氨酶（ALT）血浆浓度与糖尿病发病率之间的关系。研究设计和方法：我们对欧洲癌症和营养前瞻性调查波茨坦研究中35-65岁参与者的数据进行了病例队列分析。分析样本包括787名糖尿病患者和2224名非糖尿病患者。结果-经过广泛调整后，GGT和ALT的浓度与糖尿病的发生显著相关。与GGT最低五分位数的参与者相比，增加五分位数的校正风险比分别为1.13 （95% CI 0.66-1.93）、1.67 （95% CI 1.01-2.77）、2.77 （95% CI 1.71-4.49）和2.67 (95% CI 1.63-4.37) （P为线性趋势）
OBJECTIVE - We sought to examine the association between plasma concentrations of liver enzymes gamma-glutamyltransferase (GGT) and alanine transaminase (ALT) and incident diabetes, prospectively.RESEARCH DESIGN AND METHODS - We conducted a case-cohort analysis of data from participants mainly aged 35-65 years in the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. The analytic sample included 787 participants with incident diabetes and 2,224 participants without diabetes.RESULTS - Concentrations of GGT and ALT were significantly associated with incident diabetes after extensive adjustment. Compared with participants in the lowest quintile of GGT, the adjusted hazard ratios for increasing quintiles were 1.13 (95% CI 0.66-1.93), 1.67 (1.01-2.77), 2.77 (1.71-4.49), and 2.67 (1.63-4.37), respectively (P for linear trend