A single sip of a strong alcoholic beverage causes exposure to carcinogenic concentrations of acetaldehyde in the oral cavity
A single sip of a strong alcoholic beverage causes exposure to carcinogenic concentrations of acetaldehyde in the oral cavity
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DOI：
10.1016/j.fct.2011.05.024
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发表时间：
2011-09-01
影响因子：
4.3
通讯作者：
Vakevainen, Satu
中科院分区：
文献类型：
--
作者：
Linderborg, Klas;Salaspuro, Mikko;Vakevainen, Satu
为探讨不含乙醛或高浓度乙醛的烈性酒精饮料单口接触致癌(第1组)乙醛的情况。受试者分别品尝了不含乙醛的5ml稀释至40vol.%的乙醇和含有2400亩M乙醛的40vol.%Calvados。用气相色谱法测定唾液中乙醛和乙醇的浓度。在摄入酒精(0.5g/kg体重)后重复这一方案。在30s内，无论是有无酒精摄入(215vs.128umol/L，p<；0.05)和不饮酒(258vs.89umol/L，p<；0.05)，饮牛膝多糖后乙醛浓度显著高于喝酒精30s后的浓度。从2min开始，唾液乙醛浓度下降无显著差异，10min时仍高于致癌水平。酒精从血液到唾液的全身分布对饮用酒精饮料后的唾液乙醛没有额外的影响。乙醛的致癌浓度是在喝了一小口烈性酒精饮料后立即从口腔中的乙醇产生的，并持续至少10分钟。饮料中存在的乙醛对总乙醛暴露有短期影响。(C)2011爱思唯尔有限公司。保留所有权利。
The aim of this study was to explore oral exposure to carcinogenic (group 1) acetaldehyde after single sips of strong alcoholic beverages containing no or high concentrations of acetaldehyde.Eight volunteers tasted 5 ml of ethanol diluted to 40 vol.% with no acetaldehyde and 40 vol.% calvados containing 2400 mu M acetaldehyde. Salivary acetaldehyde and ethanol concentrations were measured by gas chromatography. The protocol was repeated after ingestion of ethanol (0.5 g/kg body weight).Salivary acetaldehyde concentration was significantly higher after sipping calvados than after sipping ethanol at 30s both with (215 vs. 128 mu mol/l, p < 0.05) and without (258 vs. 89 mu mol/l, p < 0.05) alcohol ingestion. From 2 min onwards there were no significant differences in the decreasing salivary acetaldehyde concentration, which remained above the level of carcinogenicity still at 10 min. The systemic alcohol distribution from blood to saliva had no additional effect on salivary acetaldehyde after sipping of the alcoholic beverages.Carcinogenic concentrations of acetaldehyde are produced from ethanol in the oral cavity instantly after a small sip of strong alcoholic beverage, and the exposure continues for at least 10 min. Acetaldehyde present in the beverage has a short-term effect on total acetaldehyde exposure. (C) 2011 Elsevier Ltd. All rights reserved.