Decision Making and Executive Functions in REM Sleep Behavior Disorder
Decision Making and Executive Functions in REM Sleep Behavior Disorder
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DOI：
10.5665/sleep.1828
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发表时间：
2012-05-01
期刊：
影响因子：
5.6
通讯作者：
Frauscher, Birgit
中科院分区：
文献类型：
--
作者：
Delazer, Margarete;Hoegl, Birgit;Frauscher, Birgit
研究目标：本研究旨在评估特发性REM睡眠行为障碍（iRBD）患者的决策和执行功能。IRBD通常被视为后来演变的神经退行性疾病的早期迹象，最重要的是帕金森病（PD）和路易体痴呆（DLB）。有人提出iRBD患者表现出与PD患者相似的认知特征。设计：所有参与者都进行了广泛的测试电池开发执行功能以及爱荷华州赌博任务，该任务测量了模糊情况下的决策。设置：大学医院睡眠障碍中心。参与者：16名iRBD患者和45名年龄和教育匹配的对照。干预：N.A.测量和结果：与对照组相比，iRBD患者在模糊性下表现出不利的决策，并且没有通过任务的反馈来学习。IRBD患者的决策模式的特点是缺乏一致的策略，如单一选择之间的频繁转换所示。高比例的iRBD患者（75%）甚至在任务结束时表现出随机表现或更差。没有组间差异被发现在任务评估信息采样，灵活性和分类，解决问题，和impulsivity.Conclusions：建议目前的调查，iRBD患者可能会表现出困难，在决策下的模糊性在一个阶段时，其他认知功能相对完好地保存。这是否由倾向于发生PD或DLB的患者亚组驱动，必须通过随访研究进行评估。
Study Objectives: This study was designed to assess decision making and executive functions in patients with idiopathic REM sleep behavior disorder (iRBD). IRBD is often seen as an early sign of later evolving neurodegenerative disease, most importantly Parkinson disease (PD) and Lewy body dementia (DLB). It has been proposed that iRBD patients show a cognitive profile similar to patients with PD.Design: All participants performed an extensive test battery tapping executive functions as well as the IOWA gambling task, which measures decision making under ambiguity.Setting: University hospital sleep disorders center.Participants: 16 iRBD patients and 45 age- and education-matched controls.Intervention: N.A.Measurements and Results: Compared with controls, iRBD patients showed disadvantageous decision making under ambiguity and did not learn by feedback over the task. IRBD patients' decision pattern was characterized by the lack of a consistent strategy, as indicated by frequent shifts between the single choices. A high proportion of iRBD patients (75%) showed random performance or worse even at the end of the task. No group differences were found in tasks assessing information sampling, flexibility and categorization, problem solving, and impulsivity.Conclusions: As suggested by the present investigation, iRBD patients may show difficulties in decision making under ambiguity in a stage when other cognitive functions are relatively well preserved. Whether this is driven by subgroups of patients prone to develop PD or DLB has to be assessed by follow-up investigations.