Temporal relationship between onset of positive and negative symptoms in the course of attenuated psychotic illness.
Temporal relationship between onset of positive and negative symptoms in the course of attenuated psychotic illness.
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减轻精神病过程中阳性和阴性症状发作之间的时间关系。
DOI：
10.1016/j.psychres.2020.113439
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发表时间：
2020
影响因子：
11.3
通讯作者：
Brucato,Gary
中科院分区：
文献类型：
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作者：
Dishy,Gabriella;Kennedy,Leda;Lundgren,Brooke;Xu,Qing;Masucci,MichaelD;Califano,Allegra;Hesson,Hannah;Cohen-Romano,Carol;Pia,Tyler;Brucato,Gary
对精神病临床高危人群（CHR）的研究传统上侧重于阳性和阴性症状的严重程度与综合征性精神病发展之间的关系。在这项研究中，我们检查了116名符合精神病风险综合征（SIPS）中定义的减轻阳性症状综合征标准的CHR个体出现阳性和阴性症状的时间顺序。我们发现，阳性症状出现的年龄明显比阴性症状出现的年龄小，在转换者和非转换者之间没有显著差异。这些发现可能为CHR症状的时间现象学提供重要信息。
Research in individuals at clinical high-risk (CHR) for psychosis has traditionally focused on the relationship between the severity of positive and negative symptoms and development of syndromal psychosis. In this study, we examined the temporal order of emergence of positive and negative symptoms in 116 CHR individuals who met criteria for the Attenuated Positive Symptom Syndrome defined in the Structured Interview for Psychosis-Risk Syndromes (SIPS). We found that positive symptoms emerged at a significantly younger age than negative symptoms with no significant differences between converters and non-converters. These findings may provide important information about the temporal phenomenology of CHR symptoms.