Polymeric Antimicrobial Coatings Based on Quaternary Ammonium Compounds
Polymeric Antimicrobial Coatings Based on Quaternary Ammonium Compounds
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DOI：
10.3390/coatings8010008
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发表时间：
2018-01-01
期刊：
影响因子：
3.4
通讯作者：
Kallitsis, Joannis K.
中科院分区：
文献类型：
--
作者：
Druvari, Denisa;Koromilas, Nikos D.;Kallitsis, Joannis K.
在共混和交联之后，开发了基于季铵共聚物的杀生物涂层，并且在室温或120 ℃下固化之后，研究了其作为反应性基团的比率和杀生物基团的类型的函数。为此，两个系列的共聚物与互补的反应性基团，聚（4-乙烯基苄基氯-co-丙烯酸），P（VBC-co-AAx）和聚（4-苯乙烯磺酸钠-甲基丙烯酸缩水甘油酯共聚物），P（SSNa-co-GMAx），通过自由基共聚合成，并进一步改性，导致共价键合（4-乙烯基苄基二甲基十六烷基氯化铵，VBCHAM）和静电连接的（十六烷基三甲基铵4-苯乙烯磺酸盐，SSAmC 16）单元。丙烯酸（AA）的羧基与甲基丙烯酸缩水甘油酯（GMA）的环氧基发生交联反应，通过反应共混使涂料稳定化。如此开发的涂层在室温和120摄氏度下固化，然后浸入各种浓度的超纯水和NaCl水溶液中长达三个月的时间。通过目视检查载玻片上涂层材料的完整性、重量分析法、扫描电子显微镜（SEM）表征以及测定溶液的总有机碳（TOC）和总氮（TN），研究了影响材料从基于这些系统的涂层中释放的参数。结果表明，固化温度，互补反应基团的含量，和类型的抗菌物种控制的释放水平和这些环境友好的抗菌涂料的可释放物种的性质。
Biocidal coatings that are based on quaternized ammonium copolymers were developed after blending and crosslinking and studied as a function of the ratio of reactive groups and the type of biocidal groups, after curing at room temperature or 120 degrees C. For this purpose, two series of copolymers with complementary reactive groups, poly(4-vinylbenzyl chloride-co-acrylic acid), P(VBC-co-AAx), and poly(sodium 4-styrenesulfonate-co-glycidyl methacrylate), P(SSNa-co-GMAx), were synthesized via free radical copolymerization and further modified resulting in covalently bound (4-vinylbenzyl dimethylhexadecylammonium chloride, VBCHAM) and electrostatically attached (hexadecyltrimethylammonium 4-styrene sulfonate, SSAmC16) units. The crosslinking reaction between the carboxylic group of acrylic acid (AA) and the epoxide group of glycidyl methacrylate (GMA) of these copolymers led to the stabilization of the coatings through reactive blending. The so developed coatings were cured at room temperature and 120 degrees C, and then immersed in ultra-pure water and aqueous NaCl solutions at various concentrations for a time period up to three months. Visual inspection of the integrity of the materials coated onto glass slides, gravimetry, scanning electron microscopy (SEM) characterization, as well as the determination of total organic carbon (TOC) and total nitrogen (TN) of the solutions, were used to investigate the parameters affecting the release of the materials from the coatings based on these systems. The results revealed that curing temperature, complementary reactive groups' content, and type of antimicrobial species control the release levels and the nature of releasable species of these environmentally-friendly antimicrobial coatings.