Successful treatment of interstitial lung disease related to Stevens-Johnson syndrome/toxic epidermal necrolysis overlap with etanercept: A case report and published work review
Successful treatment of interstitial lung disease related to Stevens-Johnson syndrome/toxic epidermal necrolysis overlap with etanercept: A case report and published work review
复制标题
与史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症相关的间质性肺病与依那西普重叠的成功治疗：病例报告和已发表的工作综述
DOI：
10.1111/1346-8138.15058
复制
发表时间：
2019
影响因子：
3.1
通讯作者：
e
中科院分区：
文献类型：
--
作者：
Wang Fang;Gao Xuemei;Chen Xiaohong;Tang Xuhua;Chen Haihong;Han Ji;e
间质性肺疾病（ILD）是Stevens-Johnson综合征/中毒性表皮坏死松解症（SJS/TEN）的罕见并发症。在这项研究中，我们报告了一位33岁的女性，她被诊断为与SJS/TEN重叠综合征相关的ILD。令人惊讶的是，患者对类固醇和静脉注射免疫球蛋白的联合治疗没有反应，但在两剂依那西普治疗后迅速好转。据我们所知，这是首例SJS/TEN诱导的ILD用依那西普成功治疗的病例。我们回顾了另外两例与SJS/TEN相关的ILD病例，发现与其他病例不同的是，在本病例中，ILD发生在病程早期，注射依那西普后迅速改善。我们发现，在本例患者中，血清白细胞介素- 6水平在进展期升高，在开始使用依那西普治疗后下降。
Interstitial lung disease (ILD) is a rare complication of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). In this study, we present the case of a 33‐year‐old woman who was diagnosed with ILD related to SJS/TEN overlap syndrome. Surprisingly, the patient did not respond to combination therapy with steroids and i.v. immunoglobulin, but rapidly improved after two doses of etanercept treatment. To our knowledge, this is the first case of SJS/TEN‐induced ILD that was successfully treated with etanercept. We reviewed another two cases of ILD associated with SJS/TEN, and found that unlike the other cases, in the present case, ILD occurred early in the course of the disease and rapidly improved after etanercept injection. We discovered that in the present patient, the serum interleukin‐6 level increased during the progressive stage and declined after the initiation of treatment with etanercept.