Indexes of Aortic Pressure Augmentation Markedly Underestimate the Contribution of Reflected Waves Toward Variations in Aortic Pressure and Left Ventricular Mass
Indexes of Aortic Pressure Augmentation Markedly Underestimate the Contribution of Reflected Waves Toward Variations in Aortic Pressure and Left Ventricular Mass
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DOI：
10.1161/hypertensionaha.114.04582
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发表时间：
2015-03-01
期刊：
影响因子：
8.3
通讯作者：
Norton, Gavin R.
中科院分区：
文献类型：
--
作者：
Booysen, Hendrik L.;Woodiwiss, Angela J.;Norton, Gavin R.
虽然波反射指数增强了风险预测，但主动脉收缩压增加（增强压力[Pa]或增强指数）的测量在多大程度上低估了反射波对心血管风险的影响尚不确定。在来自社区样本的参与者中（年龄bb0 ~ 16岁），我们比较了反射（反向波压和反射波指数[RI]）与增强（Pa和增强指数）压力波指数对中央主动脉脉压（PPc, n=1185）和左心室质量指数（LVMI, n=793）变化的相对贡献。主动脉血流动力学和LVMI采用径向压血仪（sphygmoor）和超声心动图测定。在不受混杂因素影响的情况下，RI和后向波压力对PPc变化的贡献大于前向波压力，而Pa和增强指数对PPc变化的贡献小于入射波压力
Although indexes of wave reflection enhance risk prediction, the extent to which measures of aortic systolic pressure augmentation (augmented pressures [Pa] or augmentation index) underestimate the effects of reflected waves on cardiovascular risk is uncertain. In participants from a community sample (age >16), we compared the relative contribution of reflected (backward wave pressures and the reflected wave index [RI]) versus augmented (Pa and augmentation index) pressure wave indexes to variations in central aortic pulse pressure (PPc; n=1185), and left ventricular mass index (LVMI; n=793). Aortic hemodynamics and LVMI were determined using radial applanation tonometry (SphygmoCor) and echocardiography. Independent of confounders, RI and backward wave pressures contributed more than forward wave pressures, whereas Pa and augmentation index contributed less than incident wave pressure to variations in PPc (P