Influence of LH/FSH releasing hormone (LRH) on the basal secretion of gonadotrophins in relation to plasma levels of oestradiol, progesterone and prolactin during the post-partum period in lactating and in non-lactating women.
Influence of LH/FSH releasing hormone (LRH) on the basal secretion of gonadotrophins in relation to plasma levels of oestradiol, progesterone and prolactin during the post-partum period in lactating and in non-lactating women.
复制标题
哺乳期和非哺乳期妇女产后期 LH/FSH 释放激素 (LRH) 对促性腺激素基础分泌与血浆雌二醇、孕酮和催乳素水平的影响。
DOI：
10.1530/acta.0.0840713
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
L. Wide
中科院分区：
文献类型：
--
作者：
S. Jeppsson;G. Rannevik;J. Thorell;L. Wide
研究了哺乳期和非哺乳期妇女产褥期垂体对LH/FSH释放激素（LRH）的反应。两组患者在足月正常分娩后8-10天、15-17天和29-32天对25杯LRH iv的反应进行了测试。分娩后10天FSH基础水平较低。然后观察到升高，并在分娩后约4周的水平高于或在正常卵泡期的上正常范围记录。泌乳组的水平显著高于泌乳组。与正常卵泡期相比，两组患者FSH基础水平的相对升高高于LH基础水平的升高。垂体对LRH无反应的时间在两组中是相等的。在两组中，FSH反应比LH反应恢复得更快。分娩后约2周，性腺激素对LRH的反应与FSH反应相反，FSH反应大于LH反应，这与在月经周期的各个阶段通常观察到的痛经妇女的反应相比。这种模式在分娩后约4周的哺乳期组更为明显。在三次测试中，每组的雌二醇水平都很低，大致相等，但在非泌乳组中，雌二醇浓度有升高的趋势。泌乳素水平在分娩后一周左右最高，然后呈下降趋势，这在非泌乳组中更为明显。两组的黄体酮水平都很低。
The pituitary responsiveness to LH/FSH releasing hormone (LRH) was studied in the puerperium in lactating and in non-lactating women. The response of both groups of patients to 25 mug LRH iv was tested 8-10 days, 15-17 days, and 29-32 days after a normal delivery at full term. The basal levels of FSH were low during the first 10 days after delivery. A rise was then observed, and about 4 weeks after delivery levels above or in the upper normal range of a normal follicular phase were recorded. The levels were significantly higher in the lactating group. When compared with the normal follicular phase, the relative increase in FSH basal levels was higher than the increase in LH basal levels in both groups of patients. The period of non-responsiveness of the pituitary to LRH was found to be of equal length in the two groups. In both groups the FSH response returned more rapidly than the LH response. About 2 weeks after delivery a reverse pattern of gonadotrophin response to LRH was seen with a FSH response that was greater than the LH response compared with what is generally observed in the various phases of the menstrual cycle in eumenorrhoeic women. This pattern was more pronounced in the lactating group about 4 weeks after delivery. Oestradiol levels were low and roughly equal on the three test occasions in each group, but in the non-lactating group there was a tendency to higher concentrations. Prolactin levels were highest about one week after delivery and then showed a tendency to decrease, and this was more pronounced in the non-lactating group. Progesterone levels were invariably low in both groups.