Regression of Myocardial Hypertrophy After Aortic Valve Replacement Faster in Women?
Regression of Myocardial Hypertrophy After Aortic Valve Replacement Faster in Women?
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DOI：
10.1161/circulationaha.109.927764
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发表时间：
2010-09-14
期刊：
影响因子：
37.8
通讯作者：
Hetzer, Roland
中科院分区：
文献类型：
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作者：
Petrov, George;Regitz-Zagrosek, Vera;Hetzer, Roland
背景：在主动脉瓣狭窄患者中，压力过载会导致心脏肥大和纤维化。雌性和雌激素影响动物模型和男性的心脏重塑和纤维化。性别差异及其在主动脉瓣置换术后肥厚消退中的分子机制尚未得到研究。方法与结果：我们前瞻性地获得92例（女性53例，男性39例）行主动脉瓣置换术治疗孤立性主动脉狭窄的患者术前和术后早期超声心动图。我们对10例左心室活检患者的基质基因表达进行了分析。此外，我们还测定了17 β -雌二醇对离体大鼠心脏成纤维细胞胶原合成的影响。术前，女性和男性的射血分数相似。女性和男性的左室直径增加的比例相似（37%和38%）。女性比男性更频繁地表现出左室肥大(女性：86%；男性：56%；P
Background-In patients with aortic stenosis, pressure overload induces cardiac hypertrophy and fibrosis. Female sex and estrogens influence cardiac remodeling and fibrosis in animal models and in men. Sex differences and their molecular mechanisms in hypertrophy regression after aortic valve replacement have not yet been studied.Methods and Results-We prospectively obtained preoperative and early postoperative echocardiography in 92 patients, 53 women and 39 men, undergoing aortic valve replacement for isolated aortic stenosis. We analyzed in a subgroup of 10 patients matrix gene expression in left ventricular (LV) biopsies. In addition, we determined the effect of 17 beta-estradiol on collagen synthesis in isolated rat cardiac fibroblasts. Preoperatively, women and men had similar ejection fraction. Similar percentages of women and men had increased LV diameters (37% and 38%). Women more frequently exhibited LV hypertrophy than men (women: 86%; men: 56%; P