Estradiol attenuates the K+-induced increase in extracellular GABA in rat striatum
Estradiol attenuates the K+-induced increase in extracellular GABA in rat striatum
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DOI：
10.1002/syn.20221
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发表时间：
2006-02-01
期刊：
影响因子：
2.3
通讯作者：
Becker, JB
中科院分区：
文献类型：
--
作者：
Hu, M;Watson, CJ;Becker, JB
雌二醇能快速直接抑制纹状体中棘神经元的l型Ca2+电流。由于中棘神经元含有γ -氨基丁酸（GABA），我们假设雌二醇抑制胞体内Ca2+通道电流会导致GABA释放减少。在本研究中，我们检测了雌二醇对纹状体透析液中GABA、牛磺酸和谷氨酸浓度的影响。为了支持我们的假设，K+引起的GABA的增加，而不是牛磺酸或谷氨酸，在雌二醇治疗后30分钟显著减弱。
Estradiol acts rapidly and directly to inhibit L-type Ca2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain gamma-aminobutyric acid (GABA), we hypothesized that estradiol inhibition of Ca2+ channel current in the cell body would result in decreased GABA release. In this study, we examined the effect of estradiol on the concentration of GABA, taurine, and glutamate in dialysate from striatum. In support of our hypothesis, the K+-evoked increase in GABA, but not taurine or glutamate, was significantly attenuated 30 min after treatment with estradiol.