Influence of cold or hyperbaric helium-oxygen environments on mouse response to a respiratory viral infection.
Influence of cold or hyperbaric helium-oxygen environments on mouse response to a respiratory viral infection.
复制标题
寒冷或高压氦氧环境对小鼠对呼吸道病毒感染反应的影响。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
Deig Ef
中科院分区：
文献类型：
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作者：
Won Wd;Ross Hc;Deig Ef
：在研究寒冷（2-3摄氏度）和低温（由于暴露于高压氦氧气氛而介导的体温下降2-3摄氏度）对小鼠对“流感”抵抗力的压力影响时，注意到这些压力对流感病毒NWS株气溶胶产生的肺部感染过程产生不利影响。相比之下，对照动物的呼吸 LD50 值约为 25 个病毒空斑形成单位 (PFU)，第 13 天发生中位死亡率。2-3°C 冷冻小鼠的 LD50 值约为 15 PFU，第 7 天中位死亡率；暴露于高压氦气的小鼠的 LD50 值约为 12 PFU，第 6 天发生中位死亡率。寒冷或高压应激会损害干扰素的产生。攻击后 24 小时观察到损伤，但 12 小时未观察到损伤，并持续数天直至小鼠濒临死亡。
: In investigating the stress effects of chilling (2-3 degrees C) and hypothermia (2-3 degrees C drop in body core temperature mediated by exposure to hyperbaric helium-oxygen atmosphere) on mouse resistance to "influenza," it was noted that these stresses adversely affected the course of pulmonary infection produced by aerosols of the NWS strain of influenza virus. Comparatively, respiratory LD50 values for control animals were about 25 virus plaque-forming units (PFU) with median mortality occurring on day 13. The LD50 values for mice chilled at 2-3 degrees C were about 15 PFU with median mortality on day 7, and for mice exposed to hyperbaric helium, about 12 PFU with median mortality on day 6. Cold or hyperbaric stress impaired interferon production. Impairment was observed at 24 h but not at 12 h post-challenge and persisted for several days until mice became moribund.