Preparation and Evaluation of Eudragit E Microspheres Containing Bacampicillin
Preparation and Evaluation of Eudragit E Microspheres Containing Bacampicillin
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巴卡西林Eudragit E微球的制备及评价
DOI：
10.3109/03639048909052532
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发表时间：
1989
影响因子：
3.4
通讯作者：
F. Kozjek
中科院分区：
文献类型：
--
作者：
M. Bogataj;A. Mrhar;A. Kristl;F. Kozjek
摘要以甲醇、丙酮、乙酸甲酯/液体石蜡/Eudradit E为聚合物，采用溶剂挥发法制备了巴氨西林微球。筛分分析表明，微球的平均粒径服从对数正态分布，平均粒径分别为123206300μm。扫描电子显微镜分析表明，所选体系均为规则球形，无团聚现象。建立了测定药物含量、药物稳定性和溶出度的高效液相色谱法。高效液相色谱分析结果表明，三种溶剂制备的微球中均存在巴氨西林的降解产物。乙酸甲酯的降解程度最低。溶出度曲线的实验值与0.顺序和组合为0。和1/2的顺序。微球与巴氨西林本身的溶出度曲线比较表明，微球具有缓释作用，可作为缓释剂。
AbstractMicrospheres with bacampicillin were prepared by the solvent evaporation method using systems methanol, acetone and methyl acetate/liquid paraffin and Eudragit E as polymer. Sieve analysis showed that the particle size of the microspheres follows log - normal distribution with average size of 123, 206 and 300 μm, respectively. Scanning electron microscopy was used to prove that all chosen systems provided the particles of regular spherical shape without aggregationHPLC method was developed for testing drug content, drug stability and dissolution. The results of HPLC analysis showed the exisistence of degradation products of bacampicillin in microspheres prepared by the use of all three solvents. The degree of degradation was the lowest in the case of methyl acetate. The experimental values of dissolution profiles fit well to 0. order and combined 0. and t½ order. The comparison of dissolution profiles of microspheres and bacampicillin itself shows that microspheres produce retard effect and theref...