Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials
Notch signaling in breast cancer and tumor angiogenesis: Cross-talk and therapeutic potentials
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DOI：
10.1007/s10911-006-9011-7
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Harris, Adrian L.
中科院分区：
文献类型：
--
作者：
Shi, Wen;Harris, Adrian L.
Notch信号转导是一种进化上保守的途径，调节许多生理过程。Notch的破坏与多种肿瘤类型有关。来自体外实验、小鼠模型和人类肿瘤样本的证据表明，Notch在乳腺癌中起主要的致癌作用，并与肿瘤发生中涉及的其他途径相互作用。此外，Notch信号传导是生理性血管生成所必需的，并且可以促进肿瘤血管生成。阻断Notch信号传导的各种策略，特别是γ-分泌酶抑制，被讨论为乳腺癌和肿瘤血管生成的潜在疗法。
Notch signaling is an evolutionarily conserved pathway that regulates numerous physiological processes. Disruption of Notch has been implicated in multiple tumor types. Evidence from in vitro experiments, mouse models and human tumor samples indicates that Notch plays a predominantly oncogenic role in breast cancer and interacts with other pathways involved in tumorigenesis. In addition, Notch signaling is required for physiological angiogenesis and may promote tumor angiogenesis. A variety of strategies for blocking Notch signaling, in particular gamma-secretase inhibition, are discussed as potential therapies for breast cancer and tumor angiogenesis.