Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events.
Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events.
复制标题
高密度脂蛋白胆固醇水平对患有 IIb 型血脂异常的老年糖尿病患者的重要性：一项为期 2 年的心血管事件调查。
DOI：
10.1111/ggi.12168
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发表时间：
2013
影响因子：
3.3
通讯作者：
Kuzuya M; Japan CDM Group
中科院分区：
文献类型：
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作者：
Ina K;Hayashi T;Araki A;Kawashima S;Sone H;Watanabe H;Ohrui T;Yokote K;Takemoto M;Kubota K;Noda M;Noto H;Ding QF;Zhang J;Yu ZY;Yoon BK;Nomura H;Kuzuya M; Japan CDM Group
目的老年Ⅱ b型糖尿病患者发生缺血性心脏病（IHD）或脑血管意外（CVA）的危险因素尚不完全清楚。因此，我们调查了血脂水平和IHD和CVA在糖尿病患者与IIb型dyslipidemies.MethodThe日本胆固醇和糖尿病研究是一项前瞻性队列研究4014 2型糖尿病患者（1936名妇女，年龄67.4 ± 9.5岁）之间的关系。主要终点是IHD或CVA的发作。研究了血脂和血糖水平以及其他与IHD或CVA发生相关的因素。IIb型血脂异常患者组共纳入462例，年龄<65岁、65-74岁和>75岁者分别为168例、190例和104例。高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇/HDL-C与年龄<65岁的IIb型血脂异常糖尿病患者的心血管事件风险显著相关，HDL-C和舒张压与65-74岁患者的心血管事件显著相关。非HDL-C与心血管事件风险无显著相关性。多元回归分析显示，较低的HDL-C与年龄<65岁和65-74岁的IIb型血脂异常糖尿病患者的心血管事件风险显著相关。结论较低的HDL-C是年龄<75岁的IIb型血脂异常糖尿病患者心血管事件的重要风险因素。Geriatr Gerontol Int 2014; 14：806-810。
AimThe risk factors for ischemic heart disease (IHD) or cerebrovascular accident (CVA) in elderly diabetic individuals with type IIb dyslipidemia are not fully known. Therefore, we investigated the relationship between lipid levels and IHD and CVA in diabetic individuals with type IIb dyslipidemia.MethodThe Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4014 type 2 diabetic patients (1936 women; age 67.4 ± 9.5 years). The primary end‐points were the onset of IHD or CVA. Lipid and glucose levels, and other factors were investigated in relation to the occurrence of IHD or CVA. A total of 462 participants were included in the group of patients with type IIb dyslipidemia.ResultsThe 462 diabetic participants with type IIb dyslipidemia were divided into those who were aged <65 years, 65–74 years and >75 years (n= 168, 190 and 104, respectively). High‐density lipoprotein cholesterol (HDL‐C) and low‐density lipoprotein cholesterol/HDL‐C were significantly associated with the risk of cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <65 years, and HDL‐C and diastolic blood pressure was significantly associated with cardiovascular events in patients aged 65–74 years. Non‐HDL‐C was not significantly associated with the risk of cardiovascular events. Multiple regression analysis showed that lower HDL‐C was significantly associated with the risk of cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <65 years and 65–74 years.ConclusionsLower HDL‐C was an important risk factor for cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <75 years.Geriatr Gerontol Int 2014; 14: 806–810.