Effects of selective attention on the electrophysiological representation of concurrent sounds in the human auditory cortex
Effects of selective attention on the electrophysiological representation of concurrent sounds in the human auditory cortex
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DOI：
10.1523/jneurosci.1402-07.2007
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发表时间：
2007-08-29
影响因子：
5.3
通讯作者：
Bertrand, Olivier
中科院分区：
文献类型：
--
作者：
Bidet-Caulet, Aurelie;Fischer, Catherine;Bertrand, Olivier
在嘈杂的环境中，我们使用听觉选择性注意来主动忽略分散注意力的声音，并选择相关信息，就像在鸡尾酒会上跟随一个特定的对话一样。本电生理学研究的目的是破译的时空组织的选择性注意的影响，同时在人类听觉皮层的声音表示。声音起始频率被操纵以诱导两个并发听觉流的分离。每个流由不同载波和调制频率的调幅音调组成。在颞叶皮层植入深部电极的耐药性部分性癫痫患者中进行电生理记录。当患者执行听觉分心任务或主动选择两个并发流中的一个时，向他们提供刺激。研究发现，选择性注意会影响初级听觉皮层的稳态反应，以及次级听觉区的瞬态和持续诱发反应。这些结果为听觉选择性注意的神经机制提供了新的见解：声音竞争过程中的流选择不仅可以通过增强相关声音的神经表征来促进，还可以通过减少听觉皮层中无关信息的表征来促进。最后，他们提出了左半球在细粒度声学信息的注意选择方面的专门化。
In noisy environments, we use auditory selective attention to actively ignore distracting sounds and select relevant information, as during a cocktail party to follow one particular conversation. The present electrophysiological study aims at deciphering the spatiotemporal organization of the effect of selective attention on the representation of concurrent sounds in the human auditory cortex. Sound onset asynchrony was manipulated to induce the segregation of two concurrent auditory streams. Each stream consisted of amplitude modulated tones at different carrier and modulation frequencies. Electrophysiological recordings were performed in epileptic patients with pharmacologically resistant partial epilepsy, implanted with depth electrodes in the temporal cortex. Patients were presented with the stimuli while they either performed an auditory distracting task or actively selected one of the two concurrent streams. Selective attention was found to affect steady-state responses in the primary auditory cortex, and transient and sustained evoked responses in secondary auditory areas. The results provide new insights on the neural mechanisms of auditory selective attention: stream selection during sound rivalry would be facilitated not only by enhancing the neural representation of relevant sounds, but also by reducing the representation of irrelevant information in the auditory cortex. Finally, they suggest a specialization of the left hemisphere in the attentional selection of fine-grained acoustic information.