CORKSCREW ENCODES A PUTATIVE PROTEIN TYROSINE PHOSPHATASE THAT FUNCTIONS TO TRANSDUCE THE TERMINAL SIGNAL FROM THE RECEPTOR TYROSINE KINASE TORSO
CORKSCREW ENCODES A PUTATIVE PROTEIN TYROSINE PHOSPHATASE THAT FUNCTIONS TO TRANSDUCE THE TERMINAL SIGNAL FROM THE RECEPTOR TYROSINE KINASE TORSO
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DOI：
10.1016/0092-8674(92)90098-w
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发表时间：
1992-07-24
期刊：
影响因子：
64.5
通讯作者：
PERRIMON, N
中科院分区：
文献类型：
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作者：
PERKINS, LA;LARSEN, I;PERRIMON, N
我们描述的果蝇基因，开瓶器（csw），这是母亲所需的细胞命运在胚胎的末端正常测定的表征。终末细胞命运的确定由信号转导途径介导，该信号转导途径涉及受体酪氨酸激酶、躯干、丝氨酸/苏氨酸激酶、D-raf和转录因子、无尾和huckebein。csw、躯干、D-raf和无尾之间的双突变体和细胞分析表明，csw作用于躯干下游，并与D-raf协同作用，通过无尾将躯干信号正向转导至下游末端基因。csw基因编码一个假定的非受体蛋白酪氨酸磷酸酶共价连接到两个N-末端SH 2结构域，这是类似于哺乳动物的PTP 1C蛋白。
We describe the characterization of the Drosophila gene, corkscrew (csw), which is maternally required for normal determination of cell fates at the termini of the embryo. Determination of terminal cell fates is mediated by a signal transduction pathway that involves a receptor tyrosine kinase, torso, a serine/threonine kinase, D-raf, and the transcription factors, tailless and huckebein. Double mutant and cellular analyses between csw, torso, D-raf, and tailless indicate that csw acts downstream of torso and in concert with D-raf to positively transduce the torso signal via tailless, to downstream terminal genes. The csw gene encodes a putative nonreceptor protein tyrosine phosphatase covalently linked to two N-terminal SH2 domains, which is similar to the mammalian PTP1C protein.