Sepsis Markers Soluble IL-2 Receptor and Soluble CD14 Subtype as Potential Biomarkers for Complete Mucosal Healing in Patients With Inflammatory Bowel Disease
Sepsis Markers Soluble IL-2 Receptor and Soluble CD14 Subtype as Potential Biomarkers for Complete Mucosal Healing in Patients With Inflammatory Bowel Disease
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DOI：
10.1093/ecco-jcc/jjx124
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发表时间：
2018-01-01
影响因子：
8
通讯作者：
Fujiwara, Yasuhiro
中科院分区：
文献类型：
--
作者：
Hosomi, Shuhei;Yamagami, Hirokazu;Fujiwara, Yasuhiro
背景和目的：需要具有高诊断准确性的新型无创生物标志物来评估炎症性肠病中与持续临床缓解相关的粘膜愈合。本研究旨在探索脓毒症标志物作为粘膜愈合的潜在生物标志物。方法：回顾性招募在内镜检查2周内接受c反应蛋白（CRP）、血清降钙素原（PCT）、可溶性白介素-2受体（sIL-2R）和血浆可溶性CD14亚型（sCD14-ST）血液检测的溃疡性结肠炎（UC）或克罗恩病（CD）患者；我们评估了标志物水平与临床特征之间的关系。粘膜完全愈合（cMH）定义为UC的Mayo内镜评分[MES]为0，CD的简单内镜评分[SES-CD]为0。结果：本研究共纳入68例UC患者和33例CD患者。UC患者中，无cMH患者的sIL-2R水平明显高于cMH患者。sIL-2R水平对UC中cMH的诊断价值最高。在CD患者中，无cMH患者CRP和sCD14-ST水平明显高于cMH患者，CRP和sCD14-ST对cMH的鉴别具有良好的诊断价值。sCD14-ST水平对于识别cMH具有很高的诊断价值，即使在临床完全缓解的CD患者中也是如此，定义为Harvey-Bradshaw指数为0。结论：UC和CD患者sIL-2R和sCD14-ST水平分别可作为炎性肠病黏膜愈合的有用替代标志物。
Background and Aims: Novel noninvasive biomarkers with high diagnostic accuracy are required to assess mucosal healing, which is associated with sustained clinical remission, in inflammatory bowel disease. This study aimed to explore sepsis markers as potential biomarkers for mucosal healing.Methods: Patients with ulcerative colitis [UC] or Crohn's disease [CD], who underwent blood tests for C-reactive protein [CRP], serum procalcitonin [PCT], soluble interleukin-2 receptor [sIL-2R], and plasma soluble CD14 subtype [sCD14-ST] within 2 weeks of endoscopy, were retrospectively recruited; and we assessed the relationship between marker levels and clinical features. Complete mucosal healing [cMH] was defined as a Mayo endoscopic subscore [MES] of 0 for UC and a simple endoscopic score for Crohn's disease [SES-CD] of 0 for CD.Results: In all, 68 UC patients and 33 CD patients were included in this study. In patients with UC, the sIL-2R level was significantly higher in patients without cMH than in those with cMH. The sIL-2R level had the highest diagnostic value for identifying cMH in UC. In patients with CD, CRP and sCD14-ST levels were significantly higher in patients without cMH than in those with cMH, and both CRP and sCD14-ST had good diagnostic values for identifying cMH. The sCD14-ST level had a high diagnostic value for identifying cMH even among CD patients with complete clinical remission, defined as a Harvey-Bradshaw index of 0.Conclusions: The sIL-2R and sCD14-ST levels in patients with UC and CD, respectively, can be useful surrogate markers for identifying mucosal healing in inflammatory bowel disease.