A ruthenium(II) complex with environment-responsive dual emission and its application in the detection of cysteine/homocysteine
A ruthenium(II) complex with environment-responsive dual emission and its application in the detection of cysteine/homocysteine
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环境响应型双发射钌(II)配合物及其在半胱氨酸/同型半胱氨酸检测中的应用
DOI：
10.1039/c2dt31180a
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Bai, Ruichun
中科院分区：
文献类型：
--
作者：
Chen, Huili;Li, Xiaokai;Bai, Ruichun
设计并合成了一种具有环境响应双重发光性能的钌多吡啶配合物[Ru（phen）（2）（IPBA）]（PF 6）（2）（配合物1）（IPBA = 4-（1H-咪唑并[4，5-f]-[1，9]菲咯啉-2-基）苯甲醛）。在非质子溶剂中，如DMSO、DMF或CH_3CN中，配合物发出强烈的青色光。当在质子溶剂中时，它发出橙子光。同样，该复合物对同型半胱氨酸和半胱氨酸（Hcy/Cys）的响应也表现出明显的溶剂依赖性。TDDFT计算表明，咪唑氮在质子溶液中的质子化是导致荧光红移的原因。因此，该复合物可用于检测非质子溶剂中的Hcy/Cys，以及在质子溶剂中。
A ruthenium polypyridine complex [Ru(phen)(2)(IPBA)](PF6)(2) (complex 1) (IPBA = 4-(1H-imidazo[4,5-f]-[1,9]phenanthroline-2-yl)benzaldehyde), which displays environment-responsive dual emissive properties, was designed and synthesized. In aprotic solvent, such as DMSO, DMF or CH3CN, the complex emits strong cyan light. When in protic solvent, it emits orange light. Similarly, the response of the complex to homocysteine and cysteine (Hcy/Cys) also shows obvious solvent dependence. TDDFT calculations reveal that the protonation of imidazole nitrogen in protic solution is responsible for the luminescent red shift. Hence, the complex could be used to detect Hcy/Cys in aprotic solvent, as well as in protic solvent.