Spatiotemporal coordination of cellular differentiation and tissue morphogenesis in organ of Corti development.
Spatiotemporal coordination of cellular differentiation and tissue morphogenesis in organ of Corti development.
复制标题
柯蒂氏器官发育中细胞分化和组织形态发生的时空协调。
DOI：
10.1007/s00795-018-0185-z
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
A.
中科院分区：
文献类型：
--
作者：
Iizuka-Kogo;A.
Corti器官是一种听觉感觉器官，是耳蜗管的一种特殊分化的上皮细胞，是内耳膜性迷路的一部分。Corti器官中的细胞一般分为两类：毛细胞和支持细胞，毛细胞负责将机械刺激的声音转换为细胞膜的电势差。这些细胞通过细胞命运的决定和分化从均一的感觉前上皮中分化出来。在Corti器官发生中，细胞分化和其位置的重新排列并行进行，导致成熟毛细胞和支持细胞的特征排列。近年来，对调控细胞命运决定和分化过程的信号分子和转录因子的研究越来越多。相比之下，人们对组织结构形成的机制知之甚少；然而，这在Corti器官的形态发生中很重要。因此，这篇综述将介绍以前的发现，重点是细胞命运决定、细胞分化和整个组织形态发生是如何在时空上以精细协调的方式进行的。这一概述提供了对CORTI发育器官中协调的调节机制的洞察。
The organ of Corti, an acoustic sensory organ, is a specifically differentiated epithelium of the cochlear duct, which is a part of the membranous labyrinth in the inner ear. Cells in the organ of Corti are generally classified into two kinds; hair cells, which transduce the mechanical stimuli of sound to the cell membrane electrical potential differences, and supporting cells. These cells emerge from homogeneous prosensory epithelium through cell fate determination and differentiation. In the organ of Corti organogenesis, cell differentiation and the rearrangement of their position proceed in parallel, resulting in a characteristic alignment of mature hair cells and supporting cells. Recently, studies have focused on the signaling molecules and transcription factors that regulate cell fate determination and differentiation processes. In comparison, less is known about the mechanism of the formation of the tissue architecture; however, this is important in the morphogenesis of the organ of Corti. Thus, this review will introduce previous findings that focus on how cell fate determination, cell differentiation, and whole tissue morphogenesis proceed in a spatiotemporally and finely coordinated manner. This overview provides an insight into the regulatory mechanisms of the coordination in the developing organ of Corti.