Experiments and Speculation on Antiviral Specificity of T and B Cells
Experiments and Speculation on Antiviral Specificity of T and B Cells
复制标题
T 和 B 细胞抗病毒特异性的实验和推测
作者：
R. Zinkernagel;K. Rosenthal
The role of T cells in anti-viral protection and in recovery from viral infections has been recognized for some time. It is also well understood that T cells functionally express dual specificity for foreign antigenic determinants expressed on target cells, as well as for some major histocompatibility gene complex (MHC) coded self determinant(s). However, it is still unknown what the nature ofthe T cell receptor molecule(s) or the nature ofthe foreign antigenic determinants is/are. So far, experimental approaches to these problems have been rather indirect. Most experiments have attempted to determine the nature of the antigens recognized by T cells, rather than the T cell receptors. The original notion that the nature of target antigens may be analyzed by the use of simple haptenic determinants such as trinitrophenyl has proven to be an illusion (Shearer et al. 1975, 1976, 1977, Dennert 1976, Forman 1976, Shearer & Schmitt-Verhulst 1977). Analysis of cytotoxic T cell responses against virus infections is not only a biologically relevant model for investigating the specificity of MHC restricted T cells, but may also lead to the development of better vaccines. For many viruses, detailed studies of the virus-induced cell surface antigens and the structural antigens have been investigated, thus providing a basis for specificity studies. In this paper we shall attempt to review studies on the specificity of MHCrestricted virus-immune cytotoxic T lymphocytes. We propose that the apparent differences between "more specific" antibodies vs. highly cross reactive cytotoxic T cells may not necessarily reflect basic differences in their respective receptor molecules and repertoires but rather reflect differing strong evolutionary pressures put on viruses by antibody dependent vs. T cell mediated immune mechanisms.
小鼠对流感病毒感染的细胞免疫反应。
影响因子：
4.3
作者：
Reiss,CS;Schulman,JL
通讯作者：
Schulman,JL