Immunostimulating influence of levamisole on nonspecific immunity in carp (Cyprinus carpio).
Immunostimulating influence of levamisole on nonspecific immunity in carp (Cyprinus carpio).
复制标题
左旋咪唑对鲤鱼（Cyprinus carpio）非特异性免疫的免疫刺激影响。
DOI：
10.1016/0145-305x(89)90021-9
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发表时间：
1989
影响因子：
2.9
通讯作者：
A. Siwicki
中科院分区：
文献类型：
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作者：
A. Siwicki
将 175 条鲤鱼分组饲养在 22 或 12°C 下，并设有匹配的对照组；每个温度下的 1 组每 3 天以颗粒形式给予 5 mg/kg 左旋咪唑，持续 15 天。将最后一次施用左旋咪唑后 1、2、4、8 和 12 周以及对照组的鲤鱼的白细胞数、硝基四唑蓝 (NBT) 减少/ml 血液和 NBT 指数制成表格。在 12 和 22°C 下，鱼中 5 或 10 mg 左旋咪唑与食物一起服用 3 个月，可增强中性粒细胞的代谢和吞噬活性，并增加吞噬细胞和白细胞的数量以及血清中溶菌酶的水平。在 22°C 下最后一次给药后 2-4 周观察到最大效果，在 12°C 下 8-12 周观察到最大效果。结论对春季预防和治疗细菌性疾病具有重要意义，左旋咪唑可增强鱼类的免疫功能。
Groups of 175 carp were kept at 22 or at 12°C, with matching control groups; 1 group at each temperature was given 5 mg/kg levamisole every 3 days in pellets for 15 days. Leukocyte numbers, nitro blue tetrazolium (NBT) reduction/ml blood, and NBT index in carp 1, 2, 4, 8 and 12 weeks after last application of levamisole, and in control groups, are tabulated. At both 12 and 22°C in fish 5 or 10 mg levamisole with food enhanced for 3 months the metabolic and phagocytic activity of neutrophils, and increased the number of phagocytic cells and leukocytes, and the level of lysosyme in serum. Maximum effects were observed 2-4 weeks after the last dose at 22°C, 8-12 weeks at 12°C. It is concluded that this has great importance for prophylaxis in spring and therapy of bacterial diseases, and that levamisole can enhance immune functions in fish.