Dexamphetamine substitution in the treatment of amphetamine abuse: an initial investigation.

Dexamphetamine substitution in the treatment of amphetamine abuse: an initial investigation.
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右旋苯丙胺替代治疗苯丙胺滥用：初步调查。

DOI：
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发表时间：
2000
期刊：
Addiction
影响因子：
6
通讯作者：
R. White
R. White
中科院分区：
医学1区
文献类型：
--
作者：
R. White

文献摘要

被引文献

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旨在 右旋苯异丙胺替代物是一种广泛使用但研究不足且有争议的苯丙胺滥用者治疗方法。本研究旨在评估替代处方对口服和静脉使用者的有用性，并找出哪些因素预测治疗效果良好。在缺乏更严格的对照试验的情况下，人们希望这项研究将有助于在迄今尚未探索的领域取得一些进展。 设计 对220名接受右旋苯丙胺处方的吸毒者的标准化记录进行了回顾性研究。其中148人获得了横断面社会人口学数据和纵向结局数据。 设置 1992年至1996年期间，安非他明使用者都参加了英格兰西南部康沃尔社区毒品小组的治疗。 结果 口服和静脉注射使用者的结果非常相似，静脉注射使用者在治疗中获得更多的整体收益。超过一半的注射者停止注射，超过三分之一的人在接受治疗后的两个月内停止注射。预测良好结果的变量在口服和静脉注射使用者之间存在差异;尽管对于两个群体来说，女性都与吸毒行为变化较慢有关，但治疗时间较长。 结论 右旋非他明处方似乎是合理的安全，并与药物使用的改善。需要进行随机试验来确定治疗的具体疗效。
AIMS Dexamphetamine substitution is a widely practised, yet under-researched and controversial treatment for amphetamine abusers. This study aimed to evaluate the usefulness of substitute prescribing, to both oral and intravenous users, and to find out which factors predict doing well in treatment. In the absence of more rigorous controlled trials, it was hoped that this study would help make some inroads into what is a hitherto unexplored area. DESIGN The standardized records of 220 users receiving dexamphetamine prescriptions were examined retrospectively. Cross-sectional socio-demographic data, and longitudinal outcome data were obtained for 148 of them. SETTING The amphetamine users had all attended and received treatment by Cornwall Community Drug Team, in the far South-West of England, during the period 1992-96. FINDINGS Oral and intravenous users had remarkably similar outcomes, with intravenous users making more overall gains in treatment. Over half the injectors stopped injecting, and more than a third within 2 months of coming into treatment. Variables predicting a good outcome differed between oral and intravenous users; although for both groups being female was associated with a slower change in drug-use behaviours, but a longer period in treatment. CONCLUSIONS Dexamphetamine prescribing appears to be reasonably safe, and is associated with improvements in drug-use. Randomized trials are warranted to determine the specific efficacy of the treatment.