Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: A long-term follow up of 204 cases in China
Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: A long-term follow up of 204 cases in China
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DOI：
10.1111/j.1440-1797.2007.00898.x
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发表时间：
2008-04-01
期刊：
影响因子：
2.5
通讯作者：
Wang, Haiyan
中科院分区：
文献类型：
--
作者：
Lv, Jicheng;Zhang, Hong;Wang, Haiyan
目的：免疫球蛋白A肾病（IgAN）是世界范围内最常见的原发性肾小球肾炎。然而，其自然历史和风险因素尚未得到很好的了解。我们的目的是确定的临床和病理因素，可以预测疾病预后在中国patients.Methods：我们研究了204活检诊断的IgA肾病患者，谁是平均随访6.1年（范围，4-15年）。根据肾脏疾病结局质量倡议实践指南分类的慢性肾脏疾病（CKD）。根据哈斯分类法对肾脏病变进行单盲分级。结果：CKD患者中1期占38.10%，2期占35.40%，3期占13.30%，4期占9.90%，5期占3.30%。在随访期间，31例患者进展为终末期肾病。活检后第5年肾存活率为85.1%，第10年为77.1%。单因素分析表明，男性、高血压、蛋白尿超过1 g/天、肾损害（估计肾小球滤过率，
Aim: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. However, its natural history and risk factors are not well understood. Our aim was to identify the clinical and pathological factors that could predict disease prognosis in Chinese patients.Methods: We studied 204 biopsy-diagnosed IgAN patients, who were followed for an average of 6.1 years (range, 4-15 years). Chronic kidney disease (CKD) classified according to the Kidney Disease Outcomes Quality Initiative practice guidelines. Renal pathological lesions were graded single-blindedly according to the Haas classification. The glomerular filtration rate was estimated by the Modification of Diet in Renal Disease equation for Chinese subjects.Results: Patients with CKD were classified as stage 1 (38.10%), stage 2 (35.40%), stage 3 (13.30%), stage 4 (9.90%) and stage 5 (3.30%). During the follow up, 31 patients had progressed to end-stage renal disease. The renal survival rate following biopsy was 85.1% at the fifth year, and 77.1% at the 10th year. Univariate analysis indicated that patients who were male, had hypertension, proteinuria of more than 1 g/day, renal impairment (estimated glomerular filtration rate,