Blood KL-6 predicts prognosis in primary Sjögren's syndrome-associated interstitial lung disease.
Blood KL-6 predicts prognosis in primary Sjögren's syndrome-associated interstitial lung disease.
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血KL-6可预测原发性干燥综合征相关间质性肺病的预后
DOI：
10.1038/s41598-022-09283-w
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发表时间：
2022-03-29
影响因子：
4.6
通讯作者：
Song JW
中科院分区：
文献类型：
--
作者：
Kim YJ;Choe J;Moon SJ;Song JW
原发性干燥综合征相关的间质性肺病（SJS-ILD）具有不同的临床病程。我们的目的是研究血液生物标志物在预测SJS-ILD预后中的作用。回顾性分析46例SJS-ILD患者的临床资料。使用多重Luminex测定（R&D Systems，Minneapolis，USA）测量血浆生物标志物水平，包括Krebs von den Lungen-6（KL-6）、CC趋化因子配体18（CCL 18）、几丁质酶-3-样-1（YKL-40）、白介素-4受体α（IL-4 Ra）和基质金属蛋白酶-7（MMP-7）。中位随访期为69.0个月。患者的平均年龄为59.4岁; 17.4%为男性。KL-6水平在非幸存者中（n = 12; 119.6 vs. 59.5 pg/mL，P = 0.037）显著高于幸存者（n = 34），而其他生物标志物的水平没有差异。受试者操作特征分析表明KL-6显示出预测生存的最佳性能（曲线下面积= 0.705，P = 0.037;最佳截止值= 53.5 pg/mL）。多变量考克斯分析（经年龄和一氧化碳弥散量校正）表明，高KL-6水平（> 53.5 pg/mL）是生存的独立预后因素（风险比= 5.939，95%置信区间1.312-26.881，P = 0.021）。我们的研究结果表明，血KL-6可能是一个有用的预测SJS-ILD患者的预后。
Interstitial lung disease associated with primary Sjögren’s syndrome (SJS-ILD) has a variable clinical course. We aimed to investigate the role of blood biomarkers in predicting prognosis for SJS-ILD. Clinical data of 46 SJS-ILD patients were retrospectively reviewed. Plasma biomarker levels, including Krebs von den Lungen-6 (KL-6), CC chemokine ligand 18 (CCL18), chitinase-3-like-1 (YKL-40), interleukin-4 receptor alpha (IL-4Ra), and matrix metalloproteinase-7 (MMP-7) were measured using the multiplex Luminex assays (R&D Systems, Minneapolis, USA). The median follow-up period was 69.0 months. The mean age of the patients was 59.4 years; 17.4% were men. The KL-6 level was significantly higher in non-survivors (n = 12; 119.6 vs. 59.5 pg/mL, P = 0.037) than survivors (n = 34), while the levels of the other biomarkers did not differ. Receiver operating characteristic analysis indicated that KL-6 shows the best performance for predicting survival (area under the curve = 0.705, P = 0.037; best cut-off value = 53.5 pg/mL). Multivariable Cox analysis that was adjusted by age and diffusing capacity for carbon monoxide suggested a high KL-6 level (> 53.5 pg/mL) as an independent prognostic factor for survival (hazard ratio = 5.939, 95% confidence interval 1.312–26.881, P = 0.021). Our results suggest that blood KL-6 might be a useful in predicting the prognosis for patients with SJS-ILD.
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影响因子：
3.7
作者：
Enomoto Y;Takemura T;Hagiwara E;Iwasawa T;Fukuda Y;Yanagawa N;Sakai F;Baba T;Nagaoka S;Ogura T
通讯作者：
Ogura T
影响因子：
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作者：
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通讯作者：
Mueller-Quernheirn, Joachim
影响因子：
5.8
作者：
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通讯作者：
Selman M
DOI：
10.1164/rccm.200403-417oc
发表时间：
2005-03-15
影响因子：
24.7
作者：
Ito, I;Nagai, S;Mishima, M
通讯作者：
Mishima, M
DOI：
10.1164/rccm.201202-0320st
发表时间：
2012-05-01
影响因子：
24.7
作者：
Meyer, Keith C.;Raghu, Ganesh;Wood, Brent
通讯作者：
Wood, Brent