The physiology of cocaine craving and 'crashing'.
The physiology of cocaine craving and 'crashing'.
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可卡因渴望和“崩溃”的生理学。
DOI：
10.1001/archpsyc.1987.01800150122018
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发表时间：
1987
影响因子：
--
通讯作者：
D. Sweeney
中科院分区：
文献类型：
--
作者：
C. Dackis;M. Gold;D. Sweeney
致编辑。在他们关于可卡因滥用者戒断症状学的文章中，Gawin和Kleber 1描述了可卡因“崩溃”综合症和其他更持久的可卡因戒断临床表现。他们建议将可卡因戒断称为神经适应，“如果第二阶段症状的生理基础得到证实”。我们已经描述了可卡因戒断的崩溃和其他症状，假设了一种生理机制，并开发了一种特定的药物治疗，2我们相信我们之前报告的研究和新的数据支持Gawin和Kleber的发现。我们的假设表明，可卡因戒断和可卡因渴望的症状主要是由多巴胺消耗引起的。2,3可卡因戒断症状，如嗜睡、失能、贪食、抑郁和精神运动迟缓，与多巴胺耗竭一致，因为它们常见于抗精神病药物治疗后，在帕金森病中也有发现。我们的假设主要是由人类可卡因滥用者的高泌乳素血症的发现所支持的
To the Editor.— In their article on abstinence symptomatology in cocaine abusers, Gawin and Kleber 1 describe the cocaine "crashing" syndrome and other more protracted clinical manifestations of cocaine abstinence. They propose the term neuroadaptation for cocaine withdrawal, "if a physiologic basis for phase 2 symptoms is substantiated." We have already described crashing and other symptoms of cocaine withdrawal, hypothesized a physiological mechanism, and developed a specific pharmacotherapy, 2 and we believe that our previously reported research and new data support the findings by Gawin and Kleber. Our hypothesis states that symptoms of cocaine withdrawal and cocaine craving result largely from dopamine depletion. 2,3 Cocaine withdrawal symptoms, such as hypersomnia, anergia, hyperphagia, depression, and psychomotor retardation, are consistent with dopamine depletion since they are commonly seen after neuroleptic treatment and are found in Parkinson's disease. Our hypothesis is primarily supported by the finding of hyperprolactinemia in human cocaine abusers, 4