Bone marrow stromal cells (bone marrow-derived multipotent mesenchymal stromal cells) for bone tissue engineering: Basic science to clinical translation
Bone marrow stromal cells (bone marrow-derived multipotent mesenchymal stromal cells) for bone tissue engineering: Basic science to clinical translation
复制标题
DOI：
10.1016/j.biocel.2010.12.006
复制
发表时间：
2011-03-01
影响因子：
4
通讯作者：
Tojo, Arinobu
中科院分区：
文献类型：
--
作者：
Kagami, Hideaki;Agata, Hideki;Tojo, Arinobu
骨组织工程是一个很有前途的再生医学领域，它利用培养的细胞、支架和成骨诱导信号来再生骨。这项技术已经在几项临床研究中使用，其疗效已有报道。在这篇综述中，我们重点介绍了骨髓基质细胞，它是骨组织工程最常用的细胞来源。对细胞的性质、适合骨组织工程的培养条件及其潜在的治疗应用进行了综述，并可能提出警告。此外，还讨论了骨髓基质细胞生物学的最新进展，以供临床翻译参考。(C)2010爱思唯尔有限公司。保留所有权利。
Bone tissue engineering is a promising field of regenerative medicine in which cultured cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. This technology has already been used in several clinical studies and its efficacy has been reported. In this review, we focus on bone marrow stromal cells, which are the most commonly used cell source for bone tissue engineering. The nature of the cells, suitable culture conditions for bone tissue engineering, and their potential therapeutic applications are reviewed with possible caveats. Furthermore, recent advances in bone marrow stromal cell biology are discussed with reference to clinical translation. (C) 2010 Elsevier Ltd. All rights reserved.