Comparison of direct measures of adiposity with indirect measures for assessing cardiometabolic risk factors in preadolescent girls.
Comparison of direct measures of adiposity with indirect measures for assessing cardiometabolic risk factors in preadolescent girls.
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DOI：
10.1186/s12937-017-0236-7
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发表时间：
2017-02-23
影响因子：
5.4
通讯作者：
Going SB
中科院分区：
文献类型：
--
作者：
Hetherington-Rauth M;Bea JW;Lee VR;Blew RM;Funk J;Lohman TG;Going SB
儿童期超重和肥胖率仍然很高，这是年轻时心脏代谢危险因素的一个原因。目前还不清楚哪些肥胖指标可以作为识别代谢风险儿童的最佳替代指标。这项研究评估了DXA衍生的肥胖直接测量是否比间接测量与儿童心脏代谢危险因素更密切相关。在288名9-12岁的女孩中获得了肥胖的人体测量和DXA测量以及心脏代谢危险因素的综合评估，其中大多数是西班牙裔。在控制成熟度和种族的同时，针对每个肥胖测量运行每个代谢参数的多元回归模型。此外，开发了包括间接和直接测量的回归模型，以评估使用肥胖的直接测量是否可以提供比单独使用间接测量更好的心脏代谢风险因素预测。除空腹血糖外，肥胖指标与心脏代谢危险因素显著相关（p < 0.05）。在调整成熟度和种族后，间接测量的肥胖占HOMA-IR的29-34%，TG的10-13%，HDL-C的14-17%和LDL-C的5-8%，而直接测量占HOMA-IR的29-34%，TG的10-12%，HDL-C的13-16%和LDL-C的5-6%。将肥胖的直接测量值添加到间接测量值中显著增加了HOMA-IR解释的方差（p = 0.04）。人体测量指标可以与更精确的直接DXA衍生肥胖指标一样用于评估青春期前女孩的大多数心血管疾病危险因素。DXA衍生的肥胖测量与间接测量一起使用可能有利于预测胰岛素抵抗风险。 NCT 02654262。2016年1月11日注册。
Childhood overweight and obesity remains high, contributing to cardiometabolic risk factors at younger ages. It is unclear which measures of adiposity serve as the best proxies for identifying children at metabolic risk. This study assessed whether DXA-derived direct measures of adiposity are more strongly related to cardiometabolic risk factors in children than indirect measures. Anthropometric and DXA measures of adiposity and a comprehensive assessment of cardiometabolic risk factors were obtained in 288, 9–12 year old girls, most being of Hispanic ethnicity. Multiple regression models for each metabolic parameter were run against each adiposity measure while controlling for maturation and ethnicity. In addition, regression models including both indirect and direct measures were developed to assess whether using direct measures of adiposity could provide a better prediction of the cardiometabolic risk factors beyond that of using indirect measures alone. Measures of adiposity were significantly correlated with cardiometabolic risk factors (p < 0.05) except fasting glucose. After adjusting for maturation and ethnicity, indirect measures of adiposity accounted for 29-34% in HOMA-IR, 10-13% in TG, 14-17% in HDL-C, and 5-8% in LDL-C while direct measures accounted for 29-34% in HOMA-IR, 10-12% in TG, 13-16% in HDL-C, and 5-6% in LDL-C. The addition of direct measures of adiposity to indirect measures added significantly to the variance explained for HOMA-IR (p = 0.04). Anthropometric measures may perform as well as the more precise direct DXA-derived measures of adiposity for assessing most CVD risk factors in preadolescent girls. The use of DXA-derived adiposity measures together with indirect measures may be advantageous for predicting insulin resistance risk. NCT02654262. Retrospectively registered 11 January 2016.