Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.
Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.
复制标题
糖化血红蛋白水平的性别差异与肥胖和抑郁症的共病相关。
DOI：
10.1089/jwh.2020.8467
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Goldstein,JillM
中科院分区：
文献类型：
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作者：
Holsen,LauraM;Huang,Grace;Cherkerzian,Sara;Aroner,Sarah;Loucks,EricB;Buka,Steve;Handa,RobertJ;Goldstein,JillM
背景：肥胖（OB）和重度抑郁症（MDD）是与疾病负担相关的慢性疾病，其合并症在女性中更为常见。连接这些疾病的机制可能涉及炎症和代谢途径。本研究的目的是评估重度抑郁症对OB与心脏代谢功能之间关系的影响，以及其中的性别差异。材料和方法：来自新英格兰家庭研究（NEFS）的成年后代在39-50岁之间进行评估，包括人体测量、心脏代谢谱分析和代谢综合征。个体按体重指数（BMI）和重度抑郁症状态分组：健康体重伴（n= 50）或无重度抑郁症（n= 95），肥胖伴（n= 79）或无重度抑郁症（n= 131）。（复发性）重度抑郁症和BMI对心脏代谢标志物的相互作用采用分位数回归模型进行检验。结果：MDD患者的糖化血红蛋白（HbA1c）明显高于无MDD患者（5.60% vs. 5.35%,p< 0.05）。伴有复发性重度抑郁症和OB的肥胖女性的HbA1c水平高于无重度抑郁症的肥胖女性（5.75%比5.44%,p< 0.05）；在男性中未观察到重度抑郁症和身体质量指数之间的相互作用。结论：我们证明了BMI和复发性重度抑郁症之间的相互作用在糖尿病风险的主要生物标志物上的性别差异，表明一个共同的代谢途径使女性易患这些合并症。需要进一步的研究来确定可能导致更有效的、性别依赖的筛查和治疗的机制。
Background:Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity appears more common among women. Mechanisms linking these conditions may involve inflammatory and metabolic pathways. The goal of this study was to evaluate the impact of MDD on relationships between OB and cardiometabolic function, and sex differences therein.Materials and Methods:Adult offspring from the New England Family Studies (NEFS) were assessed at ages 39–50, including anthropometry, cardiometabolic profile assays, and metabolic syndrome. Individuals were grouped by body mass index (BMI) and MDD status: healthy weight with (n= 50) or without MDD (n= 95) and obese with (n= 79) or without MDD (n= 131). The interaction of (recurrent) MDD and BMI on cardiometabolic markers was tested using quantile regression models.Results:Participants with MDD exhibited significantly higher hemoglobin A1c (HbA1c) than those without MDD (5.60% vs. 5.35%,p< 0.05). Women with comorbid recurrent MDD and OB had higher HbA1c levels compared to obese women without MDD (5.75% vs. 5.44%,p< 0.05); an interaction between MDD and BMI status was not observed among men.Conclusions:We demonstrated sex differences in the interaction between BMI and recurrent MDD status on a primary biomarker for diabetes risk, suggesting a common metabolic pathway predisposing women to these comorbid conditions. Further investigation is needed to identify mechanisms that may lead to more effective, sex-dependent screening and therapies.