Second messengers, ion channels and pharmacology of airway smooth muscle
Second messengers, ion channels and pharmacology of airway smooth muscle
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DOI：
10.1034/j.1399-3003.2000.01523.x
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发表时间：
2000-06-01
影响因子：
24.3
通讯作者：
Hall, IP
中科院分区：
文献类型：
--
作者：
Hall, IP
气道平滑肌细胞是调节人肺内气道口径的主要效应细胞。气道平滑肌细胞的收缩状态主要受收缩和舒张刺激平衡的影响，组胺和乙酰胆碱等物质通过激活特定的细胞表面受体和参与信号转导途径和/或离子通道而引起气道平滑肌细胞收缩。介导收缩的主要途径是激活磷脂酶C，释放肌醇1，4，5-三磷酸和升高细胞内钙水平。松弛主要通过腺苷酸环化酶偶联受体（例如β（2）-肾上腺素受体）的刺激引起，导致细胞环腺苷酸含量升高。这两条通路与气道平滑肌细胞膜上的离子通道之间存在复杂的相互作用，导致气道平滑肌张力的精细调节，对这两条通路调控机制的深入了解将有助于发现新的治疗靶点，进而为哮喘的治疗提供新的药物。
The airway smooth muscle cell is the chief effector cell governing the control of airway calibre in the human lung. The contractile state of the airway smooth muscle cell is predominantly influenced by the balance of constrictor and relaxant stimuli.Agents such as histamine and acetylcholine cause airway smooth muscle cells to contract through activation of specific cell surface receptors and engagement of signal transduction pathways and/or ion channels. The predominant pathway mediating constriction is activation of phospholipase C, with release of inositol 1,4,5-triphosphate and elevation of intracellular calcium levels.Relaxation is brought about predominantly by stimulation of adenylyl cyclase-coupled receptors (e.g. the beta(2)-adrenoceptor) resulting in elevation of cell cyclic adenosine monophosphate content. Complex crosstalk occurs between both of these pathways and also ion channels expressed on the airway smooth muscle cell membrane, leading to careful regulation of airway smooth muscle tone.A greater understanding of the mechanisms governing control of these pathways will lead to the identification of novel therapeutic targets which will in turn lead to new agents for the treatment of asthma.