Models and mechanisms of vascular dementia.
Models and mechanisms of vascular dementia.
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DOI：
10.1016/j.expneurol.2015.05.006
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发表时间：
2015-10
影响因子：
5.3
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Venkat P;Chopp M;Chen J
Vascular Dementia (VaD) is the second leading form of dementia after Alzheimer’s disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.
