Triply-responsive OEG-based microgels and hydrogels: regulation of swelling ratio, volume phase transition temperatures and mechanical properties
Triply-responsive OEG-based microgels and hydrogels: regulation of swelling ratio, volume phase transition temperatures and mechanical properties
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DOI：
10.1039/d1py00695a
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发表时间：
2021-07-13
影响因子：
4.6
通讯作者：
Saunders, Brian R.
中科院分区：
文献类型：
--
作者：
Lu, Dongdong;Zhu, Mingning;Saunders, Brian R.
温度和pH响应性微凝胶和水凝胶是一种非常有吸引力的网络体系，在生物医学工程和传感领域有着广泛的应用。体积溶胀比（Q）和体积相变温度（VPTTs）是决定凝胶应用的重要参数。聚（低聚（乙二醇）甲基醚甲基丙烯酸酯）（POEGMA）MG是有吸引力的热响应MG由于其生物相容性和可控的VPTT。在此，我们研究了一系列的pH-和热响应的聚（2-（2-甲氧基乙氧基）乙基甲基丙烯酸酯-co-甲基丙烯酸-co-乙二醇二甲基丙烯酸酯）P（MEO（2）MA-MAA-EGD）MG通过沉淀聚合。MG使用甲基丙烯酸缩水甘油酯（GMA）进行乙烯基官能化。这些乙烯基官能MG共价连接，构建多响应性的双重交联MG水凝胶（DX MG）。MG和DX MG在高pH和低温下溶胀。它们在低pH和高温下也会崩溃。MG的Q和VPTT值可以通过MAA含量和pH精确调节。MG和DX MG还表现出对离子种类（阳离子）的响应。我们比较了DX MG和母体MG的溶胀趋势。加入Na+、Mg 2+和Al 3+或Fe 3+离子可以改变DX MG的机械性能和溶胀。后者通过RCOO-基团提供离子交联。我们相信，这项工作提供了更好的洞察力，设计和控制多响应MG和DX MG的属性。
Thermally- and pH-responsive microgels (MGs) and hydrogels are fascinating network systems that have been applied in biomedical engineering and sensing. The volume-swelling ratio (Q) and the volume-phase transition temperatures (VPTTs) are important parameters that govern the gels applications. Poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA) MGs are attractive thermal-responsive MGs due to their biocompatibility and controllable VPTTs. Herein, we investigate a series of pH- and thermal-responsive poly (2-(2-methoxyethoxy) ethyl methacrylate-co-methacrylic acid-co-ethyleneglycol dimethacrylate) P(MEO(2)MA-MAA-EGD) MGs via precipitation polymersation. The MGs are vinyl-functionalised using glycidyl methacrylate (GMA). These vinyl functional MGs were covalently interlinked to construct the multi-responsive doubly crosslinked MG hydrogels (DX MGs). The MGs and DX MGs swell at high pH and low temperature. They also collapse at low pH and high temperature. The Q and VPTT values of MGs can be regulated precisely by the MAA content and pH. The MGs and DX MGs also exhibit responses to ionic species (cations). We compare the swelling tendencies of the DX MGs and parent MGs. The mechanical properties and swelling of the DX MGs can be changed using added Na+, Mg2+ and Al3+ or Fe3+ ions. The latter provides ionic crosslinking via the RCOO- groups. We believe this work provides improved insight for designing and controlling the properties of multi-responsive MGs and DX MGs.