On the actions that one nerve cell can have on another: Distinguishing "drivers" from "modulators"
On the actions that one nerve cell can have on another: Distinguishing "drivers" from "modulators"
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DOI：
10.1073/pnas.95.12.7121
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发表时间：
1998-06-09
影响因子：
11.1
通讯作者：
Guillery, RW
中科院分区：
文献类型：
--
作者：
Sherman, SM;Guillery, RW
当一个神经细胞作用于另一个神经细胞时，其突触后效应可能会有很大差异。在感觉系统中，来自“驱动器”的输入可以与“调制器”的输入区分开来。驱动器可以被识别为感受野属性的发送者；调制器可以被识别为改变该传输的某些方面的概率。在感受野不可用的情况下，区分就更加困难并且目前尚未定义。我们利用视觉通路，特别是丘脑膝状体中继（有很多相关证据）来探索区分驱动器和调节器的方法。考虑这种区别在多大程度上首先适用于丘脑的其他部分，然后可能适用于大脑的其他部分。我们建议进行以下区别： 来自驱动器输入的互相关图比来自调制器的互相关图具有更尖锐的峰值；对于任何一个细胞来说，可能只有很少的驱动器，但有很多调制器；驱动剂可能仅通过具有快速突触后效应的离子型受体起作用，而调节剂也可能激活具有缓慢且持久的突触后效应的代谢型受体。
When one nerve cell acts on another, its postsynaptic effect can vary greatly. In sensory systems, inputs from "drivers" can be differentiated from those of "modulators." The driver can be identified as the transmitter of receptive field properties; the modulator can be identified as altering the probability of certain aspects of that transmission. Where receptive fields are not available, the distinction is more difficult and currently is undefined. We use the visual pathways, particularly the thalamic geniculate relay for which much relevant evidence is available, to explore ways in which drivers can be distinguished from modulators. The extent to which the distinction may apply first to other parts of the thalamus and then, possibly, to other parts of the brain is considered. We suggest the following distinctions: Cross-correlograms from driver inputs have sharper peaks than those from modulators; there are likely to be few drivers but many modulators for any one cell; and drivers are likely to act only through ionotropic receptors having a fast postsynaptic effect whereas modulators also are likely to activate metabotropic receptors having a slow and prolonged postsynaptic effect.