Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2:: implication for prostate cancer risk
Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2:: implication for prostate cancer risk
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DOI：
10.1038/sj.pcan.4500753
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发表时间：
2004-12-01
影响因子：
4.8
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Kakinuma, H;Tsuchiya, N;Kato, T
类固醇激素相关基因的多态可能会影响终生雄激素暴露，从而改变前列腺癌发病的风险。为探讨CYP17和SRD5A2基因多态性对血清类固醇激素水平的影响，对164名日本男性进行了血清激素水平和启动子区T-C碱基替换和SRD5A2(V89L)基因多态性的检测。在无血清睾酮和雄烯二酮水平上发现了不同的CYP17基因的线性趋势，提示了CYP17基因多态性在决定循环雄激素水平中的重要性。
Polymorphism of the steroid hormone-related genes might affect life-long androgen exposure, thus altering a risk of prostate cancer incidence. To evaluate the effect of the polymorphisms of CYP17 and SRD5A2 on serum steroid hormone levels, the 164 male Japanese cohort were tested for serum hormone levels and the genotype of the polymorphisms of CYP17 (T-C base substitution in the promoter region) and SRD5A2 (V89L). The linear trends across the CYP17 genotypes in serum-free testosterone and androstenedione levels were found, suggesting the importance of the polymorphism of CYP17 in determining the circulating androgen levels.