Telomerase reverse transcriptase and neurodegenerative diseases.
Telomerase reverse transcriptase and neurodegenerative diseases.
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DOI：
10.3389/fimmu.2023.1165632
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发表时间：
2023
影响因子：
7.3
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中科院分区：
文献类型：
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神经退行性疾病（ND）是导致神经系统进行性损伤的慢性病症，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和肌萎缩侧索硬化症（ALS）。年龄是ND的主要危险因素。端粒缩短是细胞衰老的生物学标志，端粒酶逆转录酶（TERT）通过维持端粒长度来减缓这一过程。血脑屏障（BBB）使大脑成为一个独特的免疫器官，虽然中枢神经系统中存在的T细胞数量有限，但它们在ND中发挥着重要作用。研究表明，ND可以通过调节外周T细胞免疫应答来影响，并且TERT可能在T细胞衰老和ND中起重要作用。本文就端粒酶逆转录酶在神经营养不良中的研究现状作一综述，并探讨端粒酶逆转录酶、T细胞和神经营养不良之间的潜在联系。对衰老和端粒的进一步研究可能为开发年龄相关疾病的治疗策略提供有价值的见解。
Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS). Age is a major risk factor for NDs. Telomere shortening is a biological marker of cellular aging, and telomerase reverse transcriptase (TERT) has been shown to slow down this process by maintaining telomere length. The blood-brain barrier (BBB) makes the brain a unique immune organ, and while the number of T cells present in the central nervous system is limited, they play an important role in NDs. Research suggests that NDs can be influenced by modulating peripheral T cell immune responses, and that TERT may play a significant role in T cell senescence and NDs. This review focuses on the current state of research on TERT in NDs and explores the potential connections between TERT, T cells, and NDs. Further studies on aging and telomeres may provide valuable insights for developing therapeutic strategies for age-related diseases.