Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes
Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes
复制标题
微藻凝胶贴片中的溶解氧可促进糖尿病慢性伤口愈合。
DOI：
10.1126/sciadv.aba4311
复制
发表时间：
2020-05-01
期刊：
影响因子：
13.6
通讯作者：
Wu, Jinhui
中科院分区：
文献类型：
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作者：
Chen, Huanhuan;Cheng, Yuhao;Wu, Jinhui
糖尿病的慢性伤口有发展成糖尿病足溃疡的终生风险。氧气通过调节细胞增殖、迁移和新生血管对伤口愈合至关重要。然而，目前的氧疗法，包括高压氧（HBO）和局部气态氧（TGO），主要采用气态氧输送，穿透皮肤的效果要差得多。在这里，我们介绍一个产氧贴片，由活的微藻水凝胶制成，可以产生溶解氧。这种贴片的优异性能源于它的溶解氧输送，比TGO穿透皮肤的效率高100倍。进一步的实验表明，该贴片能够促进细胞的增殖、迁移和试管形成，并改善糖尿病小鼠的慢性创面愈合和移植皮肤的存活。我们认为微藻凝胶贴片可以提供持续溶解氧，促进慢性伤口愈合。
Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers. Oxygen is crucial to wound healing by regulating cell proliferation, migration, and neovascularization. However, current oxygen therapies, including hyperbaric oxygen (HBO) and topical gaseous oxygen (TGO), mainly employ gaseous oxygen delivery, which is much less effective in penetrating the skin. Here, we introduce an oxygen-producing patch, made of living microalgae hydrogel, which can produce dissolved oxygen. The superior performance of the patch that results from its dissolved oxygen delivery is >100-fold much more efficient than TGO penetrating the skin. Further experiments indicate that the patch could promote cell proliferation, migration, and tube formation in vitro, and improve chronic wound healing and the survival of skin grafts in diabetic mice. We believe that the microalgae-gel patch can provide continuous dissolved oxygen to improve chronic wound healing.