IL-2 signals through Sgkl and inhibits proliferation and apoptosis in kidney cancer cells
IL-2 signals through Sgkl and inhibits proliferation and apoptosis in kidney cancer cells
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DOI：
10.1007/s00109-007-0205-2
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发表时间：
2007-07-01
影响因子：
4.7
通讯作者：
Perrotti, Nicola
中科院分区：
文献类型：
--
作者：
Amato, Rosario;Menniti, Miranda;Perrotti, Nicola
白细胞介素-2是淋巴细胞存活和功能所必需的细胞因子。IL-2受体在上皮组织中的异位表达以前已有报道，尽管这种表达的功能意义仍在研究中。我们提供了新的结构和功能信息的表达IL-2受体在肾癌细胞和其他正常和肿瘤的人类上皮组织。在A-498肾癌细胞中，我们发现IL-2与其自身受体的结合触发了导致增殖抑制和凋亡的信号转导途径。我们发现，增殖的抑制与Erk 1/2去磷酸化，而生存信号似乎是由Sgk 1激活介导的。本研究的重点是IL-2诱导的调节Sgk 1和描述的作用，IL-2受体和Sgk 1的调节上皮肿瘤细胞的死亡和存活。
The interleukin-2 is a cytokine that is essential for lymphocytic survival and function. Ectopic expression of the IL-2 receptor in epithelial tissues has been reported previously, although the functional significance of this expression is still being investigated. We provided novel structural and functional information on the expression of the IL-2 receptor in kidney cancer cells and in other normal and neoplastic human epithelial tissues. In A-498 kidney cancer cells, we showed that IL-2 binding to its own receptor triggers a signal transduction pathway leading to the inhibition of proliferation and apoptosis. We found that the inhibition of proliferation is associated with Erk1/2 dephosphorylation, whereas the survival signals appear to be mediated by Sgk1 activation. This investigation focuses on the IL-2 induced regulation of Sgk1 and describes a role of the IL-2 receptor and Sgk1 in the regulation of epithelial tumor cell death and survival.