Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue
Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue
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DOI：
10.1038/s41551-021-00723-y
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发表时间：
2021-05-27
影响因子：
28.1
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
--
作者：
Song, Enming;Xie, Zhaoqian;Rogers, John A.
在软组织表面之下的深处，以高精度和真实的时间评估软组织的生物力学，将开辟诊断机会。在这里，我们报告的小型化电磁设备的开发和应用，每个集成的振动致动器和软应变传感片，用于动态测量的杨氏模量的皮肤和其他软组织的深度约为1-8毫米，这取决于传感器的特定设计。我们通过实验和计算建立了这些设备的工作原理，并使用一系列合成和生物材料以及健康志愿者的人体皮肤评估了它们的性能。装置阵列可用于在空间上映射弹性模量并描绘模量的深度分布。作为一个实际的医疗效用的例子，我们表明，该设备可用于准确定位与银屑病相关的病变。用于快速和精确地对活组织进行机械表征的紧凑型电子设备可用于监测和诊断一系列健康疾病，包括振动致动器和软应变传感片的电磁设备可以动态地测量皮肤和其他软生物组织的杨氏模量，深度为毫米。
Evaluating the biomechanics of soft tissues at depths well below their surface, and at high precision and in real time, would open up diagnostic opportunities. Here, we report the development and application of miniaturized electromagnetic devices, each integrating a vibratory actuator and a soft strain-sensing sheet, for dynamically measuring the Young's modulus of skin and of other soft tissues at depths of approximately 1-8 mm, depending on the particular design of the sensor. We experimentally and computationally established the operational principles of the devices and evaluated their performance with a range of synthetic and biological materials and with human skin in healthy volunteers. Arrays of devices can be used to spatially map elastic moduli and to profile the modulus depth-wise. As an example of practical medical utility, we show that the devices can be used to accurately locate lesions associated with psoriasis. Compact electronic devices for the rapid and precise mechanical characterization of living tissues could be used to monitor and diagnose a range of health disorders.Electromagnetic devices involving a vibratory actuator and a soft strain-sensing sheet can dynamically measure the Young's modulus of skin and of other soft biological tissues at depths of millimetres.