Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial
Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial
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DOI：
10.1093/humrep/16.5.868
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发表时间：
2001-05-01
影响因子：
6.1
通讯作者：
Bahceci, M
中科院分区：
文献类型：
--
作者：
Akman, MA;Erden, HF;Bahceci, M
IVF中反应不良者的管理一直是一个大问题，理想的方法尚未制定。在这项研究中，我们的目的是比较两种替代刺激方案。共纳入48例既往周期中描述的不良反应患者，并分为两组：I组24例患者，24个周期，其中醋酸亮丙瑞林（40 μ g s.c.在周期第2天开始使用促性腺激素（每天），然后在周期第3天使用外源性促性腺激素; II组24例，共24个周期，其中促性腺激素释放激素（GnRH）拮抗剂促排卵（西曲瑞克，在卵泡晚期每天0.25mg）给药虽然只有在HCG当天组II的雌二醇浓度低于组I，两组间临床妊娠率和种植率无显著性差异，两种方案对卵巢刺激不良反应者的影响似乎相同，需要更大样本量的进一步随机研究来确定这些结果。
The management of poor responders in IVF has always been a big problem, The ideal approach has yet to be formulated. In this study we aim to compare two alternative stimulation protocols. A total of 48 poor responder patients described from previous cycles were included and grouped into two: group I consisted of 24 patients in 24 cycles in which leuprolide acetate (40 mug s.c. per day) was initiated on cycle day 2 followed by exogenous gonadotrophins on cycle day 3; group II consisted of 24 patients in 24 cycles in which ovarian stimulation included gonadotrophin-releasing hormone (GnRH) antagonist (cetrorelix, 0.25 mg daily during late follicular phase) administration While only the oestradiol concentrations on the day of HCG were lower in group II compared with group I, the clinical pregnancy and implantation rates among groups did not show any significance, The impact of these two regimens in ovarian stimulation of poor responders seem to be same and to establish these results further randomized studies with larger sample sizes are required.