Estimation of time of divergence from phylogenetic studies.
Estimation of time of divergence from phylogenetic studies.
复制标题
系统发育研究中分歧时间的估计。
DOI：
10.1139/g77-024
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. Chakraborty
中科院分区：
文献类型：
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作者：
R. Chakraborty
近期对同源DNA碱基序列或同源蛋白质氨基酸序列的比较数据研究表明，同时估算系统发育结构和分化时间往往既繁琐又耗时。另一方面，当进化树的拓扑结构已知时，本文表明，在假设每个分支发生均匀随机替换的情况下，可以应用最小二乘法理论来获得进化树每个分支相对时间长度的简单估算值。该方法通过各种球蛋白分子和细胞色素c的氨基酸序列数据进行了说明。还讨论了一些估算值的进化意义。
Recent studies with comparative data on base sequences of homologous DNA's or amino acid sequences of homologous proteins indicate that simultaneous estimation of phylogenetic structure and time of divergence is often cumbersome and time consuming. On the other hand, when the topology of an evolutionary tree is known, it is shown in this paper that the least squares theory may be applied to obtain simple estimates of the relative time lengths for each segment of the tree under the assumption of uniform random substitutions in each segment. The method is illustrated with amino acid sequence data on various globin molecules and cytochrome c. The evolutionary significance of some of the estimates is also discussed.