Dorsal premotor neurons encode the relative position of the hand, eye, and goal during reach planning
Dorsal premotor neurons encode the relative position of the hand, eye, and goal during reach planning
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DOI：
10.1016/j.neuron.2006.05.025
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发表时间：
2006-07-06
期刊：
影响因子：
16.2
通讯作者：
Andersen, Richard A.
中科院分区：
文献类型：
--
作者：
Pesaran, Bijan;Nelson, Matthew J.;Andersen, Richard A.
当我们伸手抓住一个物体时，我们通常会一起移动手臂和凝视方向。这些动作是如何协调的？为了研究这个问题，我们研究了两只猴子的背侧运动前区(PMD)和顶内侧区域(MIP区)的神经元活动，同时系统地改变了手和眼睛在伸展时的起始位置。PMD神经元编码目标、手和眼睛的相对位置。MIP神经元仅编码眼睛的目标位置。这些结果表明，MIP在以眼睛为中心的参考帧中编码目标位置，而PMD使用相对位置代码来指定所有三个变量之间的位置差异。这种相对位置编码通过计算手部和眼睛的相对位置，可能在协调手部和眼睛运动方面发挥重要作用。
When reaching to grasp an object, we often move our arm and orient our gaze together. How are these movements coordinated? To investigate this question, we studied neuronal activity in the dorsal premotor area (PMd) and the medial intraparietal area (area MIP) of two monkeys while systematically varying the starting position of the hand and eye during reaching. PMd neurons encoded the relative position of the target, hand, and eye. MIP neurons encoded target location with respect to the eye only. These results indicate that whereas MIP encodes target locations in an eye-centered reference frame, PMd uses a relative position code that specifies the differences in locations between all three variables. Such a relative position code may play an important role in coordinating hand and eye movements by computing their relative position.