QUANTITATIVE MAGNETIC-RESONANCE-IMAGING OF HUMAN BRAIN PERFUSION AT 1.5-T USING STEADY-STATE INVERSION OF ARTERIAL WATER
QUANTITATIVE MAGNETIC-RESONANCE-IMAGING OF HUMAN BRAIN PERFUSION AT 1.5-T USING STEADY-STATE INVERSION OF ARTERIAL WATER
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DOI：
10.1073/pnas.91.1.33
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发表时间：
1994-01-04
影响因子：
11.1
通讯作者：
LEIGH, JS
中科院分区：
文献类型：
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作者：
ROBERTS, DA;DETRE, JA;LEIGH, JS
我们报告我们的经验，使用非侵入性磁共振技术定量成像的人脑灌注在1.5 T。该技术使用磁性反转动脉水作为自由扩散的血流示踪剂。灌注图像是根据在有和没有动脉血液反转的情况下采集的磁共振图像以及根据表观自旋-晶格弛豫时间的图像来计算的。在15分钟的采集时间内，从9名志愿者获得了分辨率约为1 x 2 x 5 mm的单层灌注图。分析得出灰质的平均灌注率为93 +/- 16 ml.100 g-1.min-1，白色物质为38 +/- 10 ml.100 g-1.min-1，全脑为52 +/- 8 ml·100 g-1·min-1。在过度通气和屏气期间观察到灌注的显著变化。该技术可用于定量测量人脑中的灌注，而没有使用外源性示踪剂的方法的风险和费用。
We report our experience using a noninvasive magnetic resonance technique for quantitative imaging of human brain perfusion at 1.5 T. This technique uses magnetically inverted arterial water as a freely diffusible blood flow tracer. A perfusion image is calculated from magnetic resonance images acquired with and without arterial blood inversion and from an image of the apparent spin-lattice relaxation time. Single-slice perfusion maps were obtained from nine volunteers with approximately 1 x 2 x 5-mm resolution in an acquisition time of 15 min. Analysis yielded average perfusion rates of 93 +/- 16 ml.100 g-1.min-1 for gray matter, 38 +/- 10 ml.100 g-1.min-1 for white matter, and 52 +/- 8 ml.100 g-1.min-1 for whole brain. Significant changes in perfusion were observed during hyperventilation and breath holding. This technique may be used for quantitative measurement of perfusion in human brain without the risks and expense of methods which use exogenous tracers.