Impaired memory for scenes but not faces in developmental hippocampal amnesia: A case study
Impaired memory for scenes but not faces in developmental hippocampal amnesia: A case study
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DOI：
10.1016/j.neuropsychologia.2007.11.007
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发表时间：
2008-01-01
期刊：
影响因子：
2.6
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
--
作者：
Bird, Chris M.;Vargha-Khadem, Faraneh;Burgess, Neil
在乔恩身上测试了对陌生面孔和场景的项目识别，乔恩患有双侧海马病理学导致的发育性遗忘症。在健康成人的性能和信心的判断表明，这两个测试等同的难度，并有类似的接收器操作特性（ROC）。乔恩在面部测试中的表现与对照组没有什么区别，无论是灵敏度还是ROC曲线的形状。相比之下，他在场景测试中的表现明显较差，他的ROC与标准的双过程（DP;回忆和熟悉）模型和识别记忆的不等方差信号检测模型不一致。Jon的数据与对照组的数据通过DP模型拟合良好，DP模型包括两个回忆参数，但需要与正常回忆和受损熟悉度相对应的反直觉参数值，这可能反映了当他对材料的记忆力较弱时对信心判断的特殊使用。结果突出了使用ROC来估计患者的回忆和熟悉度的局限性，这些患者可能已经为他们难以记住的材料（场景，但在这种情况下不是面孔）制定了补偿策略。总的来说，这些数据很难与海马在记忆中的作用的域一般帐户，包括双过程模型和声明模型。相反，这些数据表明，海马体在地形记忆的处理中起着优先的作用。(c)2007爱思唯尔有限公司保留所有权利。
Item recognition for unfamiliar faces and scenes was tested in Jon, who has developmental amnesia resulting from bilateral hippocampal pathology. Performance and confidence judgements in healthy adults showed that both tests were equated for difficulty and had similar receiver operating characteristics (ROCs). Jon's performance on the faces test was indistinguishable from the controls, in both sensitivity and the shape of the ROC curve. In contrast his performance on the scenes test was markedly poor, and his ROC was inconsistent with both a standard dual process (DP; recollection and familiarity) model and an unequal variance signal detection model of recognition memory. Jon's data were as well fitted as controls' data by a DP model that included two recollection parameters, but required counter-intuitive parameter values corresponding to normal recollection and impaired familiarity, which likely reflect an idiosyncratic use of confidence judgements when his memory for the material is weak. The results highlight a limitation in using ROCs to estimate recollection and familiarity in patients who may have developed compensatory strategies for material that they have difficulty remembering (scenes, but not faces in this case). Overall, these data are difficult to reconcile with domain-general accounts of the hippocampal role in memory, including dual process models and the declarative model. Instead, the data indicate that the hippocampus plays a preferential role in the processing of topographical memoranda over faces memoranda. (c) 2007 Elsevier Ltd. All rights reserved.