Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy
Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy
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DOI：
10.1097/01.aog.0000189096.94874.9c
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发表时间：
2006-01-01
影响因子：
7.2
通讯作者：
Tribe, RM
中科院分区：
文献类型：
--
作者：
Dann, AT;Kenyon, AP;Tribe, RM
目的：妊娠期肝内胆汁淤积症与血脂异常有关，但妊娠期血脂与临床诊断的关系尚不清楚。本研究的目的是对妊娠期肝内胆汁淤积症和妊娠瘙痒症患者的血脂进行详细分析。对63例妊娠期肝内胆汁淤积症患者的非空腹血标本进行了血脂浓度测定（n = 54，在诊断时招募，n = 9，后来发展为疾病），43名患有妊娠瘙痒症的妇女，结果：妊娠期肝内胆汁淤积症与血脂异常有关。妊娠期肝内胆汁淤积症患者的低密度脂蛋白（LDL）胆固醇、载脂蛋白B-100和总胆固醇浓度在妊娠期间显著升高，与妊娠瘙痒症和对照组相比，LDL胆固醇在临床诊断前升高。妊娠期肝内胆汁淤积症患者的高密度脂蛋白胆固醇水平低于妊娠期瘙痒症患者。结论：肝内胆汁淤积症与血脂异常有关，这可能是肝内胆汁淤积症的病理机制之一。
OBJECTIVE: Intrahepatic cholestasis of pregnancy is associated with dyslipidemia, but the gestational lipid profile in relation to clinical diagnosis of the disease is unknown. The aim of this study was to undertake a detailed analysis of plasma lipids in women presenting with intrahepatic cholestasis of pregnancy and pruritus gravidarum.METHODS: Plasma lipid concentrations were assessed in nonfasting blood samples from 63 women with intrahepatic cholestasis of pregnancy (n = 54, recruited at the time of diagnosis, and n = 9, who later developed the disease), 43 women with pruritus gravidarum, and 26 healthy pregnant controls during pregnancy and at 4-6 weeks postpartum.RESULTS: Intrahepatic cholestasis of pregnancy was associated with an abnormal lipid profile. Low-density lipoprotein (LDL) cholesterol, apolipoprotein B-100, and total cholesterol concentrations were significantly raised during pregnancy in women with intrahepatic cholestasis of pregnancy compared with pruritus gravidarum and controls and LDL-cholesterol was raised before clinical diagnosis. High-density lipoprotein cholesterol was lower in women with intrahepatic cholestasis of pregnancy compared with the pruritus gravidarum group. Ursodeoxycholic acid did not alter plasma lipid concentrations.CONCLUSION: Intrahepatic cholestasis is associated with dyslipidemia, which may contribute to the patho-