Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells
Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells
复制标题
DOI：
10.1007/978-3-030-55454-5_11
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yukina Nishito;Shuangyu Luo;T. Kambe
中科院分区：
文献类型：
--
作者：
Yukina Nishito;Shuangyu Luo;T. Kambe
锌是人体必需的微量元素。锌作为许多蛋白质的结构、催化和信号成分起着关键作用，缺乏锌会引起多种病理生理症状。虽然一个成年人体内只含有2-3克锌，但人体有多达23个锌转运蛋白，这表明严格的时空调节系统和细胞锌稳态对身体健康无疑是至关重要的。近年来对锌代谢的认识在分子水平上确定了锌转运体在生理和病理中的重要性。然而，虽然已知特定的锌转运蛋白在锌从管腔摄取或释放到门静脉血流中以输送到外周组织中发挥着独特的作用，但这些过程的分子机制仍只被部分理解。本章描述了锌在肠上皮细胞中载体运输的分子机制，重点介绍了锌吸收不可或缺的锌转运蛋白，并比较了锌在肠上皮细胞中的载体运输与铁、铜、锰的载体运输。
Zinc is an essential trace element in humans. As zinc plays pivotal roles as a structural, catalytic, and signaling component of many proteins, its deficiency causes diverse pathophysiological symptoms. Although an adult human body contains only 2–3 g of zinc, humans have as many as 23 zinc transporters, highlighting that strict spatiotemporal regulation of both systemic and cellular zinc homeostases is undoubtedly crucial for good health. Recent progress understanding zinc metabolism has determined the importance of zinc transporters in physiology and pathology at a molecular level. Yet while specific zinc transporters are known to play distinct roles in either zinc uptake from the lumen or release into the portal bloodstream for delivery to the peripheral tissues, the molecular mechanisms underlying these processes remain only partially understood. This chapter describes the molecular mechanism underlying vectorial zinc transport in intestinal epithelial cells, with a focus on zinc transporters indispensable for zinc absorption, and compares and contrasts vectorial transepithelial zinc transport with vectorial transepithelial iron, copper, and manganese transport.