REGULATORY FUNCTIONS OF UBIQUITIN AND SUMO IN DNA REPAIR PATHWAYS
REGULATORY FUNCTIONS OF UBIQUITIN AND SUMO IN DNA REPAIR PATHWAYS
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DOI：
10.1007/978-1-4419-6676-6_15
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Mueller, Stefan
中科院分区：
文献类型：
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作者：
Jentsch, Stefan;Mueller, Stefan
泛素和相扑是结构相关的蛋白质修饰剂，共价连接到靶蛋白质的赖氨酸残基上。虽然泛素传统上被认为是蛋白酶体降解的信号，但它的非降解作用在控制细胞关键过程中同样重要。同样，相扑体系主要以一种非退化的方式发挥作用。越来越多的证据表明，泛素和相扑的这些非蛋白分解功能在DNA损伤反应网络的控制中尤为重要，该网络协调一系列DNA修复途径，使细胞能够应对不同类型的遗传毒性应激。在本章中，我们将说明泛素和相扑在控制选定的DNA修复途径中的一些关键功能。
Ubiquitin and SUMO are structurally related protein modifiers that are covalently attached to lysine residues of target proteins. While ubiquitin is traditionally known as a signal for proteasomal degradation, its nondegradative actions are equally important in the control of cellular key processes. Similarly, the SUMO system primarily acts in a nondegradative manner. Accumulating evidence indicates that these nonproteolytic functions of ubiquitin and SUMO are particularly important in the control of the DNA damage response network, which coordinates a set of DNA repair pathways and allows cells to cope with different types of genotoxic stress. In this chapter we will illustrate some key functions of ubiquitin and SUMO in the control of selected DNA repair pathways.